COPD and Occupational Exposures: A Case-Control Study

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• Personal Author:
  Breen V ; Buist AS ; Doney B ; Graziani M ; Heumann M ; Hnizdo, Eva ; McBurnie MA ; Villnave J ; Vollmer WM ; Weinmann S
• Description:
  Objective: Evidence demonstrates that occupational exposures are causally linked with chronic obstructive pulmonary disease (COPD). This case-control study evaluated the association between occupational exposures and prevalent COPD based on lifetime occupational history. Methods: Cases (n = 388) aged 45 years and older with COPD were compared with controls (n = 356), frequency matched on age, sex, and cigarette smoking history. Odds ratios for exposure to each of eight occupational hazard categories and three composite measures of exposure were computed using logistic regression. Results: Occupational exposures most strongly associated with COPD were diesel exhaust, irritant gases and vapors, mineral dust, and metal dust. The composite measures describing aggregate exposure to gases, vapors, solvents, or sensitizers (GVSS) and aggregate exposure to dust, GVSS, or diesel exhaust were also associated with COPD. In the small group of never-smokers, a similar pattern was evident. Conclusion: These population-based findings add to the literature linking occupational exposures to COPD. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Case Reports Dust Irritants Metals Occupational Diseases Occupational Exposure Occupational Health Respiratory Tract Diseases Safety Smoke Smokers Solvents Tobacco Products Vehicle Emissions

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• Keywords:
  Case-studies Chronic-exposure Diesel-exhausts Dusts Gases Irritant-gases Metal-dusts Mineral-dusts Occupational-diseases Occupational-exposure Organic-dusts Organic-solvents Organic-vapors Pulmonary-system-disorders Respiratory-system-disorders Smoking Solvent-vapors Statistical-analysis Surveillance Tobacco-smoke Vapors

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• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Oregon ; OSHA Region 10 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  50
• Issue:
  5
• NIOSHTIC Number:
  nn:20034238
• Citation:
  J Occup Environ Med 2008 May; 50(5):561-569
• Contact Point Address:
  Sheila Weinmann, PhD, Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Avenue, Portland, OR 97227
• Email:
  sheila.weinmann@kpchr.org
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  All Sectors
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:83589a470cad386a6e9e6ba1a9c8741b83558b28a47920af8ce0e6c4f1fd8472f567454838274cd4610661ce6c647c89eae7f01bc67babe9b78a62a3d56a5f3f
• Download URL:
  https://stacks.cdc.gov/view/cdc/189535/cdc_189535_DS1.pdf
• File Type:
  [PDF - 1.23 MB ]