Welding Fume Exposure and Associated Inflammatory and Hyperplastic Changes in the Lungs of Tumor Susceptible A/J Mice

Details

• Personal Author:
  Antonini JM ; Castranova, Vincent ; Hubbs, Ann F. ; Reynolds SH ; Roberts, Jennifer R. ; Solano-Lopez C ; Taylor MD ; Young SH ; Zeidler-Erdely PC
• Description:
  It has been suggested that welding fume (WF) exposure increases lung cancer risk in welders. Epidemiology studies have failed to conclude that WF alone causes lung cancer and animal studies are lacking. We examined the course of inflammation, damage, and repair in the lungs of A/J mice, a lung tumor susceptible strain, caused by stainless steel WF. Mice were exposed by pharyngeal aspiration to 40 mg/kg of WF, silica, or saline. Bronchoalveolar lavage (BAL) was performed 24 hours, 1 and 16 weeks to assess lung injury and inflammation and histopathology was done 1, 8, 16, 24, and 48 weeks postexposure. Both exposures increased inflammatory cells, lactate dehydrogenase and albumin at 24 hr and 1 week. At 16 weeks, these parameters remained elevated in silica-exposed but not WF-exposed mice. Histopathologic evaluation at 1 week indicated that WF induced bronchiolar epithelial hyperplasia with associated cellular atypia, alveolar bronchiolo-alveolar hyperplasia (BAH) in peribronchiolar alveoli, and peribronchiolar lymphogranulomatous inflammation. Persistent changes included foci of histiocytic inflammation, fibrosis, atypical bronchiolar epithelial cells, and bronchiolar BAH. The principle changes in silica-exposed mice were histiocytic and suppurative inflammation, fibrosis, and alveolar BAH. Our findings that WF causes persistent bronchiolar and peribronchiolar epithelial changes, suggest a need for studies of bronchiolar changes after WF exposure. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Aluminum Silicates Animals Environmental Monitoring Epidemiology Laboratories Lung Lung Diseases Neoplasms Occupational Diseases Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide Welding

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• Keywords:
  Animal-studies Exposure-assessment Exposure-levels Fumes Fumigants Laboratory-animals Lung-cancer Lung-disorders Occupational-diseases Occupational-exposure Occupational-hazards Occupational-health Pulmonary-system-disorders Silica-dusts Silicates Welders Welders-lung Welding-industry

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• ISSN:
  0192-6233
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  364-372
• Volume:
  34
• Issue:
  4
• NIOSHTIC Number:
  nn:20030625
• Citation:
  Toxicol Pathol 2006 Jul-Aug; 34(4):364-372
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Work Environment and Workforce: Mixed Exposures
• Peer Reviewed:
  True
• Source Full Name:
  Toxicologic Pathology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:41df67a1a7ce762dee686f2b3941bd1b719f1c64e34cdc6d86e271932a8ba7e5ae74263d97e5cc04d8f95c0ddcc814cfdea10e64428c2a86d21a7dad8dfcc35a
• Download URL:
  https://stacks.cdc.gov/view/cdc/191170/cdc_191170_DS1.pdf
• File Type:
  [PDF - 3.16 MB ]