History and Results of the Two Inter-Laboratory Round Robin Endotoxin Assay Studies on Cotton Dust

Details

• Personal Author:
  Burgess JL ; Fluharty K ; Hysong T ; Johnson VJ ; Kashon MK ; Luster MI ; Yucesoy, Berran
• Description:
  Specific genotypes of cytokine genes (such as IL-l, TGFB and TNFa) have been associated with chronic obstructive lung disease and a rapid decline of lung function. Based on this, the influence of genetic variations in cytokine genes, which may modify the coded protein levels and/or activity, on the risk of rapid decline in lung function in firefighters was investigated. IL-lB +3953, TGFB -509, TNFa -308 and TNFa -238 single nucleotide polymorphisms were examined in 445 fire fighters recruited during their annual medical surveillance examinations and assessed for associations between genotypes and longitudinal rate of decline in lung function measured by prior annual medical surveillance including FVC and FEV1 The presence of IL-lB +3953 and TNFa -238 variants were found to be associate with the rate of decline in lung function (p<0.05) as measured by FEV1. These data suggest that IL-1B + 3953 and TNFa -238 variants may influence individual susceptibility for accelerated decline in lung function in firefighters. [Description provided by NIOSH]
• Subjects:
  Firefighters Genetics Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Diseases Fire-fighters Fire-fighting Genes Lung-disease Lung-disorders Lung-function Pulmonary-system-disorders Respiratory-system-disorders
• ISSN:
  1546-3222
• Publisher:
  American Thoracic Society
• Document Type:
  Text
• Funding:
  Interagency Agreement
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Arizona ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2
• NIOSHTIC Number:
  nn:20030118
• Citation:
  Proc Am Thorac Soc 2005 May; 2(Abstracts):A920
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of the American Thoracic Society. 2005 ATS International Conference, May 20-25, 2005, San Diego, California
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4be0cb9a4f6131ae6a522aac0982b14caa43fd5452917fe718fe2de441ff2f7933cc6886bd60b31fceb62b26200d075e6e076892c7cc2f3621ee62870f2c825c
• Download URL:
  https://stacks.cdc.gov/view/cdc/190939/cdc_190939_DS1.pdf
• File Type:
  [PDF - 466.98 KB ]