Association of Cytokine Gene Polymorphisms with Rate of Decline in Lung Function

Details

• Personal Author:
  Burgess JL ; Fluharty K ; Guerra S ; Johnson VJ ; Kashon ML ; Kurzius-Spencer M ; Luster MI ; Yucesoy, Berran
• Description:
  Objective: To investigate whether genetic variants involved in cytokine expression are associated with the age-related rate of decline in forced expiratory volume in 1 second (FEV1). Methods: Functional polymorphisms in the TNF[alpha], TGF[beta]1, IL-1[beta], IL-1RN, IL-13, and IL-8 genes were investigated in 374 active firefighters with at least five pulmonary function tests. Results: A protective effect was found between the presence of the TGF[beta]1 -509 TT genotype and rate of decline in FEV1 (P = 0.043). Carrying an A allele at TNF[alpha] -308 (P = 0.010) and GG genotype at TNF[alpha] -238 (P = 0.028) was associated with a more rapid rate of FEV1 decline. The TNF[alpha] -308A/-238G haplotype was also associated with an increased rate of decline as compared with the other haplotypes. Conclusions: Interindividual variability in progressive decline in FEV1 may be explained in part by genetic variations within genes involved in inflammatory responses. [Description provided by NIOSH]
• Subjects:
  Genetics Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Diseases Genes Lung-disease Lung-disorders Lung-function Pulmonary-system-disorders Respiratory-system-disorders
• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  50
• Issue:
  8
• NIOSHTIC Number:
  nn:20034035
• Citation:
  J Occup Environ Med 2008 Jun; 50(8):642-648
• Contact Point Address:
  Berran Yucesoy, PhD, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888
• Email:
  byucesoy@cdc.gov
• Federal Fiscal Year:
  2008
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:af2e6e0e9faf554631fc699810a613a2d44c8055df68df2602bf4ac51674325a17341e6dbb6748586dea6f57645f6aee8c44c6f4832c47e188ca508904b551e3
• Download URL:
  https://stacks.cdc.gov/view/cdc/189417/cdc_189417_DS1.pdf
• File Type:
  [PDF - 206.16 KB ]