Effects of Exposure to Organic Solvents on Menstrual Cycle Length

Details

• Personal Author:
  Chen D ; Cho SI ; Christiani, David C. ; Damokosh AI ; Hu YA ; Ryan LM ; Smith, Thomas J. ; Xu X ; Chen D ; Cho SI ; Christiani, David C. ; Damokosh AI ; Hu YA ; Ryan LM ; Smith, Thomas J. ; Xu X
• Description:
  To investigate the association between organic solvent exposure and menstrual disturbance, we conducted a cross-sectional study among 1408 petrochemical workers in China. Based on an industrial hygiene evaluation, we classified the workshops according to the presence or absence of organic solvents (benzene, styrene, toluene, or xylene). We used logistic regression to estimate odds ratios and 95% confidence intervals for prolonged menstrual cycle length (oligomenorrhea: average cycle length > 35 days during the previous year) associated with the exposure. After adjustment for confounders, each additional year of work in an exposed workshop was associated with a 7% increase in oligomenorrhea (odds ratio, 1.07; 95% confidence interval, 1.00 to 1.14). Compared with no exposure, 3 or more years of exposure was associated with a 53% increase in oligomenorrhea (odds ratio, 1.53; 95% confidence interval, 1.00 to 2.34). We concluded that exposure to organic solvents is associated with a trend toward increased frequency of oligomenorrhea. [Description provided by NIOSH]
• Subjects:
  Occupational Exposure Occupational Health Petroleum Risk Assessment Risk Factors Safety Solvents Women
• Keywords:
  Analytical Methods Chemical Hypersensitivity Exposure Assessment Humans Occupational Exposure Organic Solvents Petroleum Industry Risk Factors
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  43
• Issue:
  6
• NIOSHTIC Number:
  nn:20029664
• Citation:
  J Occup Environ Med 2001 Jun; 43(6):567-575
• Contact Point Address:
  Dr Xiping Xu, Associate Professor and Director, Program for Population Genetics, Department of Environmental Health, Harvard School ofPublic Health, 665 Huntington Avenue, FXB-101, Boston, MA 02115-6096
• Email:
  xu@hsph.harvard.edu
• CAS Registry Number:
  Ammonia (CAS RN 7664-41-7) ; Benzene (CAS RN 71-43-2) ; Hydrogen sulfide (CAS RN 7783-06-4) ; Manganese (CAS RN 7439-96-5) ; Ammonia (CAS RN 7664-41-7) ; Benzene (CAS RN 71-43-2) ; Hydrogen sulfide (CAS RN 7783-06-4) ; Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Disease and Injury: Fertility and Pregnancy Abnormalities ; Disease and Injury: Fertility and Pregnancy Abnormalities
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19921201
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  19990131
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:722002728a05b8de37d7430d624382030a4e05c5c3c06a6628d8eea62fc10616d60735b42b15c9993187914adb4c84b4e8dc5a208ca5bbb321728461594496eb
• Download URL:
  https://stacks.cdc.gov/view/cdc/190596/cdc_190596_DS1.pdf
• File Type:
  [PDF - 161.05 KB ]