Nested Case-Control Study of External Ionizing Radiation Dose and Mortality from Dementia Within a Pooled Cohort of Female Nuclear Weapons Workers

Details

• Personal Author:
  Moscato BS ; Natarajan N ; Sibley RF ; Wilkinson, Gregg S.
• Description:
  A prior investigation of this cohort of female nuclear workers found increased deaths from mental disorders, including dementia. The present study estimates the effect of workplace exposures to ionizing radiations and other hazards on mortality from dementia. A nested case-control study within a pooled cohort of 67,976 female nuclear workers compared 91 cases of death from dementia with 910 controls. Adjusted odds ratios (ORs) were employed to estimate the effects of maximum annual and total lifetime radiation doses on the occurrence of dementia in 168 monitored workers. Both maximum annual (OR = 2.11, 95% confidence interval (CI) = 0.98, 4.40) and total lifetime radiation doses (OR = 2.09, 95% CI = 1.02, 4.29) were associated with death from dementia. Significant dose-response trends were present for both exposures. Occupational exposure to ionizing radiation (IR) may be associated with increased risk of death from dementia in female workers. Since these findings are based on a small number of cases, replication with a larger case sample should be pursued. [Description provided by NIOSH]
• Subjects:
  Case Reports Demography Epidemiology Mental Disorders Mental Health Mortality Occupational Exposure Occupational Health Radiation Safety Sex Characteristics Women

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• Keywords:
  Case-studies Demographic-characteristics Ionizing-radiation Mental-disorders Mortality-data Mortality-rates Occupational-exposure Radiation-effects Radiation-exposure Sex-factors Workers

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  351-358
• Volume:
  44
• Issue:
  4
• NIOSHTIC Number:
  nn:20029244
• Citation:
  Am J Ind Med 2003 Oct; 44(4):351-358
• Contact Point Address:
  Ralph F. Sibley, Department of Family Medicine, State University of New York, Buffalo, 462 Grider St., Buffalo, NY 14215
• Email:
  rsibley@buffalo.edu
• Federal Fiscal Year:
  2004
• Performing Organization:
  Department of Social and Preventive Medicine, 270 Farber Hall, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
• Peer Reviewed:
  True
• Start Date:
  19970930
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  19990929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d83c1d72791092719fbca2a31ffaa7bbdc2d8a720baa9849809e83bb80bd47165d84c3d22196aee3fc988414418f06a7d4c4aeffc507e838320caa954b2930a5
• Download URL:
  https://stacks.cdc.gov/view/cdc/190277/cdc_190277_DS1.pdf
• File Type:
  [PDF - 113.59 KB ]