A Nested Case-Control Study of Leukemia Mortality and Ionizing Radiation at the Portsmouth Naval Shipyard

Details

• Personal Author:
  Chen PH ; Couch, James R. ; Daniels, Robert D. ; Kinnes, Gregory M. ; Kubale, Travis L. ; Nowlin SJ ; Schubauer-Berigan, Mary K. ; Silver, Sharon R. ; Yiin JH
• Description:
  A nested case-control study using conditional logistic regression was conducted to evaluate the exposure-response relationship between external ionizing radiation exposure and leukemia mortality among civilian workers at the Portsmouth Naval Shipyard (PNS), Kittery, Maine. The PNS civilian workers received occupational radiation exposure while performing construction, overhaul, repair and refueling activities on nuclear-powered submarines. The study age-matched 115 leukemia deaths with 460 controls selected from a cohort of 37,853 civilian workers employed at PNS between 1952 and 1992. In addition to radiation doses received in the workplace, a secondary analysis incorporating doses from work-related medical X rays and other occupational radiation exposures was conducted. A significant positive association was found between leukemia mortality and external radiation exposure, adjusting for gender, radiation worker status, and solvent exposure duration (OR = 1.08 at 10 mSv of exposure; 95% CI = 1.01, 1.16). Solvent exposure (including benzene and carbon tetrachloride) was also significantly associated with leukemia mortality adjusting for radiation dose, radiation worker status, and gender. Incorporating doses from work-related medical X rays did not change the estimated leukemia risk per unit of dose. [Description provided by NIOSH]
• Subjects:
  Case Reports Demography Mortality Neoplasms Occupational Exposure Occupational Health Radiation Risk Assessment Safety Sex Characteristics
• Keywords:
  Cancer Case-studies Demographic-characteristics Ionization Mortality-data Mortality-rates Occupational-exposure Radiation-effects Radiation-exposure Risk-analysis Sex-factors

  More +
• ISSN:
  0033-7587
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  164
• Issue:
  6
• NIOSHTIC Number:
  nn:20028980
• Citation:
  Radiat Res 2005 Dec; 164(6):810-819
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  True
• Source Full Name:
  Radiation Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0dc952f7c04b01fd2d50585167135a3602859838ea9cc4836019fd17d5ce1a3c3926252839ca1c4cfbf977b96fd46e52297b4cdf936ed8103a275b60fad674c2
• Download URL:
  https://stacks.cdc.gov/view/cdc/190066/cdc_190066_DS1.pdf
• File Type:
  [PDF - 205.19 KB ]