Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Ferrieri, Patricia ; Lynfield, Ruth ; Creti, Roberta ; Flores, Aurea E.
Ferrieri, Patricia ; Lynfield, Ruth ; Creti, Roberta ; Flores, Aurea E. Less -
Description:
Group B Streptococcus (GBS) is a major cause of invasive disease in neonates in the United States. Surveillance of invasive GBS disease in Minnesota, USA, during 2000-2010 yielded 449 isolates from 449 infants; 257 had early-onset (EO) disease (by age 6 days) and 192 late-onset (LO) disease (180 at age 7-89 days, 12 at age 90-180 days). Isolates were characterized by capsular polysaccharide serotype and surface-protein profile; types III and Ia predominated. However, because previously uncommon serotype IV constitutes 5/31 EO isolates in 2010, twelve type IV isolates collected during 2000-2010 were studied further. By pulsed-field gel electrophoresis, they were classified into 3 profiles; by multilocus sequence typing, representative isolates included new sequence type 468. Resistance to clindamycin or erythromycin was detected in 4/5 serotype IV isolates. Emergence of serotype IV GBS in Minnesota highlights the need for serotype prevalence monitoring to detect trends that could affect prevention strategies.
Subject:
[+]
Anti-Bacterial Agents
Clindamycin
CME
DNA, Bacterial
Drug Resistance, Bacterial
Electrophoresis, Gel, Pulsed-Field
Erythromycin
Genotype
Humans
Infant
Infant, Newborn
Multilocus Sequence Typing
Retrospective Studies
Serotyping
Streptococcal Infections
Streptococcus Agalactiae

Source:
Emerg Infect Dis. 19(4):551-558.
Document Type:
Journal Article
Place as Subject:
Minnesota
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:68af47dd41cdb63a0ddf4a0b122fa2a2596767934447bde31ee76aa20666c33f
File Type:

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