Serotype IV and Invasive Group B Streptococcus Disease in Neonates, Minnesota, USA, 2000–20101

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ferrieri, Patricia ; Lynfield, Ruth ; Creti, Roberta ; Flores, Aurea E.
• Description:
  Group B Streptococcus (GBS) is a major cause of invasive disease in neonates in the United States. Surveillance of invasive GBS disease in Minnesota, USA, during 2000-2010 yielded 449 isolates from 449 infants; 257 had early-onset (EO) disease (by age 6 days) and 192 late-onset (LO) disease (180 at age 7-89 days, 12 at age 90-180 days). Isolates were characterized by capsular polysaccharide serotype and surface-protein profile; types III and Ia predominated. However, because previously uncommon serotype IV constitutes 5/31 EO isolates in 2010, twelve type IV isolates collected during 2000-2010 were studied further. By pulsed-field gel electrophoresis, they were classified into 3 profiles; by multilocus sequence typing, representative isolates included new sequence type 468. Resistance to clindamycin or erythromycin was detected in 4/5 serotype IV isolates. Emergence of serotype IV GBS in Minnesota highlights the need for serotype prevalence monitoring to detect trends that could affect prevention strategies.
• Subjects:
  Anti-Bacterial Agents Clindamycin CME DNA, Bacterial Drug Resistance, Bacterial Electrophoresis, Gel, Pulsed-Field Erythromycin Genotype Humans Infant Infant, Newborn Multilocus Sequence Typing Retrospective Studies Serotyping Streptococcal Infections Streptococcus Agalactiae

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• Source:
  Emerg Infect Dis. 19(4):551-558.
• Document Type:
  Journal Article
• Place as Subject:
  Minnesota
• Location:
  North America
• Volume:
  19
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:68af47dd41cdb63a0ddf4a0b122fa2a2596767934447bde31ee76aa20666c33f
• Download URL:
  https://stacks.cdc.gov/view/cdc/19018/cdc_19018_DS1.pdf
• File Type:
  [PDF - 532.58 KB ]