Validation of Biomarkers for Silica Exposure

Details

• Personal Author:
  Castranova, Vincent ; Donaldson K ; Downs K ; Girdler-Brown B ; Gulumian M ; Madidi N ; Murray J ; Ndlovu Z ; Vallyathan V
• Description:
  Silicosis is a preventable fibrotic lung disease caused by silica exposure. Current methods to diagnose silicosis use x rays, although a 10-15 year lag period generally occurs between exposure and radiological changes. Silicosis is used as an end point for assessing silica exposure. Biomarkers are specific physiological or biochemical traits that indicate the onset and progress of a disease or condition. They can provide information on the very early effects of exposure, and thus make an important contribution to risk assessment, which could provide an early indication of the risk of developing silicosis. A cross sectional study will be performed on three groups: gold miners with silicosis (radiologically diagnosed); gold miners exposed to silica but without silicosis; and a control group of persons never exposed to silica. Biomarkers previously identified in an international workshop will be assayed in the peripheral blood of the study participants. Receiver Operating Curves (ROC) will be used to identify the tests that provide sufficient discrimination between exposed and unexposed and few false positives and negatives. Baseline levels will be determined for the chosen biomarkers in the three groups, allowing validation of biomarkers of crystalline silica exposure and silicosis. Promising biomarkers will be developed into risk assessment tools that can provide risk information soon after exposure in a future study. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Biomarkers Environmental Monitoring Lung Diseases Mining Occupational Diseases Occupational Exposure Occupational Health Radiography Respiratory Tract Diseases Risk Assessment Risk Factors Safety Silicon Dioxide

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• Keywords:
  Diseases Exposure-assessment Exposure-levels Gold-mines Lung-disease Miners Occupational-diseases Occupational-exposure Pulmonary-system-disorders Respiratory-system-disorders Risk-analysis Risk-factors Silica-dusts Silicates Silicosis X-ray-analysis

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• Publisher:
  World Health Organization
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20029112
• Citation:
  IOHA 2005. 6th International Scientific Conference of the International Occupational Hygiene Association, 19-23 September, 2005, Pilanesberg National Park, North West Province, South Africa. Geneva, Switzerland: World Health Organization, 2005 Sep; :216
• Email:
  Kerry.Downs@nioh.nhls.ac.za
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  False
• Source Full Name:
  IOHA 2005. 6th International Scientific Conference of the International Occupational Hygiene Association, 19-23 September, 2005, Pilanesberg National Park, North West Province, South Africa
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7fcf79754a0e8aa0a1670b1db7fd4471d08b84d400c7579f628c2a9c58d658679927644d017ad9a4d06fba41dfd8b320e1a3b63746b17a08fd3e93ca5b38452d
• Download URL:
  https://stacks.cdc.gov/view/cdc/190165/cdc_190165_DS1.pdf
• File Type:
  [PDF - 282.66 KB ]