Airway Responses to the Inhalation of Cotton Dust and Cotton Bract Extracts

Details

• Personal Author:
  Bluhm EC ; Buck M ; Castranova, Vincent ; Godbold J ; Roy N ; Schachter EN ; Siegel, Paul D. ; Whitmer M ; Witek TJ ; Zuskin E
• Description:
  Exposure to dust in the cotton industry is associated with respiratory dysfunction. Healthy subjects challenged with cotton bract extract (CBE) develop transient airway hyperresponsiveness. CBE, a major component of cotton dust, is potentially an important agent for studying byssinosis. To compare airway responses to cotton dust extract (CDE) and CBE in healthy subjects. In 21 healthy, non-smoking subjects we compared the effects of CBE and CDE in a double-blind random order, following a 10-min aerosol inhalation. The response to methacholine (MCh) 2 h following CBE or CDE was measured. Lung function was recorded using maximal (MEFV) and partial expiratory flow volume (PEFV) curves, measuring MEF at 60% of baseline vital capacity below total lung capacity [MEF(40%)(P)] on the PEFV curve. Responders were subjects who developed a 20% or greater fall in MEF(40%)(P) following extract challenge. Endotoxin levels were low for CBE (5.71 EU/mg) and CDE (31.88 EU/mg). There were 18 responders to CBE and 17 responders to CDE.The average maximal falls in MEF(40%)(P) were 70 +/- 4.9 and 70 +/- 4.4% of baseline (nonsignificant) following CBE and CDE, respectively. All subjects enhanced their MCh response following CBE or CDE. The MCh dose which reduced MEF(40%)(P) by 40% was identical for CBE and CDE (1.3 mug/ml). We conclude that CBE and CDE exert similar physiologic effects. [Description provided by NIOSH]
• Subjects:
  Aerosols Byssinosis Dust Gossypium Lung Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Aerosol-particles Author Keywords: Airway Hyperresponsiveness Cotton-dust Cotton-industry Cotton Bract Cotton Dust Dust-particles Dusts Inhalation-studies Lung-function Occupational-exposure Physiological-effects Respiratory-system-disorders

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• ISSN:
  0025-7931
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  41-47
• Volume:
  73
• Issue:
  1
• NIOSHTIC Number:
  nn:20029007
• Citation:
  Respiration 2006 Feb; 73(1):41-47
• Contact Point Address:
  E. Neil Schachter, MD, Mount Sinai School of Medicine, Box 1232, One Gustave L. Levy Place, New York, NY 10029-6574, USA
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  Mount Sinai School of Medicine, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19880701
• Source Full Name:
  Respiration
• End Date:
  20020331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c6387309555e36f6f138cc5560eb63143b2d806836ec81e3e79f6d80935cf111afeef615f89fb879bbdff38d7a8c6031d292820d07900bd67f27e659f7093133
• Download URL:
  https://stacks.cdc.gov/view/cdc/190084/cdc_190084_DS1.pdf
• File Type:
  [PDF - 129.47 KB ]