Airway hyperresponsiveness due to cotton bract extract.

Details

• Personal Author:
  Buck MG ; Fein E ; Godbold J ; Lehnert BE ; Rienzi N ; Russomanno J ; Schachter EN ; Siegel J ; Witek TJ Jr. ; Zuskin E
• Description:
  Studies were conducted to determine both the effect of previous cigarette smoking on cotton bract extract (CBE) hyperresponsiveness and the effect of repeated challenge with CBE to healthy persons who were not cigarette smokers. In the first part of the study, airway reactivity to methacholine was investigated before and after inhaling CBE in 28 nonsmokers and 50 smokers. On the day following baseline measurement of airway reactivity to methacholine, the study subjects first inhaled CBE. Significant drops in lung function were determined in nine of the 28 nonsmokers and 27 of the 50 smokers. A second study was also conducted in which 27 nonsmokers were studied to determine their reaction to inhalation challenge with CBE. Subjects were challenged with CBE on five consecutive days and again after 2 days. Airway reactivity to methacholine was determined 90 minutes after CBE challenge. Lung function decline was accentuated on day one and eight in the nonsmokers undergoing repeated daily challenge with CBE. This was not found on days two through five. The authors conclude that inhalation of CBE causes a characteristic initial airway response in healthy nonsmoking individuals. This response was reduced as exposure was repeated; bronchospasm recurred after a period of no challenge. Post bronchospasm hyperreactivity to methacholine was induced by CBE in responders. Airway reactivity was enhanced by smoking and the response to CBE was accentuated. The authors also conclude that the amount of smoking a worker did was not in any way related to the enhanced reactivity of CBE so that an index might be developed. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Byssinosis Dust Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety Smokers Tobacco Products
• Keywords:
  NIOSH-Grant; Pulmonary-system-disorders; Plant-dusts; Respiratory-system-disorders; Cotton-dust; Byssinosis; Humans; Cigarette-smoking; Pulmonary-function
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Georgia ; New York ; OSHA Region 2 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-69
• NIOSHTIC Number:
  nn:00213703
• NTIS Accession Number:
  PB93215143
• Citation:
  Department of Internal Medicine, Mount Sinai School of Medicine, New York, New York 1992 Nov; :1-69
• Contact Point Address:
  Medicine Mount Sinai Medical Center One Gustave L Levy Place New York, N Y 10029
• Federal Fiscal Year:
  1993
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  False
• Start Date:
  19880701
• Source Full Name:
  Department of Internal Medicine, Mount Sinai School of Medicine, New York, New York
• End Date:
  20020331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246260/cdc_246260_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]