Circovirus in Tissues of Dogs with Vasculitis and Hemorrhage

Li, Linlin; McGraw, Sabrina; Zhu, Kevin; Leutenegger, Christian M.; Marks, Stanley L.; Kubiski, Steven; Gaffney, Patricia; Dela Cruz Jr, Florante N.; Wang, Chunlin; Delwart, Eric; Pesavento, Patricia A.

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Circovirus in Tissues of Dogs with Vasculitis and Hemorrhage

Supporting Files Public Domain

Apr 2013
By Li, Linlin ; McGraw, Sabrina ; Zhu, Kevin ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Li, Linlin ; McGraw, Sabrina ; Zhu, Kevin ; Leutenegger, Christian M. ; Marks, Stanley L. ; Kubiski, Steven ; Gaffney, Patricia ; Dela Cruz Jr, Florante N. ; Wang, Chunlin ; Delwart, Eric ; Pesavento, Patricia A.
Description:

We characterized the complete genome of a novel dog circovirus (DogCV) from the liver of a dog with severe hemorrhagic gastroenteritis, vasculitis, and granulomatous lymphadenitis. DogCV was detected by PCR in fecal samples from 19/168 (11.3%) dogs with diarrhea and 14/204 (6.9%) healthy dogs and in blood from 19/409 (3.3%) of dogs with thrombocytopenia and neutropenia, fever of unknown origin, or past tick bite. Co-infection with other canine pathogens was detected for 13/19 (68%) DogCV-positive dogs with diarrhea. DogCV capsid proteins from different dogs varied by up to 8%. In situ hybridization and transmission electron microscopy detected DogCV in the lymph nodes and spleens of 4 dogs with vascular compromise and histiocytic inflammation. The detection of a circovirus in tissues of dogs expands the known tropism of these viruses to a second mammalian host. Our results indicate that circovirus, alone or in co-infection with other pathogens, might contribute to illness and death in dogs.
Subjects:

Animals Circoviridae Infections Circovirus Diarrhea DNA, Viral Dog Diseases Dogs Feces Female Gastrointestinal Hemorrhage Genome, Viral Humans In Situ Hybridization Liver Lymph Nodes Male Phylogeny Polymerase Chain Reaction Research Spleen Vasculitis
Source:

Emerg Infect Dis. 19(4):534-541.
Document Type:

Journal Article
Place as Subject:

California
Location:

North America
Volume:

19
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:b5127e726ad21901017ce71903e04ed57db2c857ca7330a06b3f46bcf0b8691f
Download URL:

https://stacks.cdc.gov/view/cdc/18993/cdc_18993_DS1.pdf
File Type:

[PDF - 469.13 KB ]

File Language:

English

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