i
Circovirus in Tissues of Dogs with Vasculitis and Hemorrhage
-
Apr 2013
-
-
Source: Emerg Infect Dis. 19(4):534-541.
Details:
-
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Description:We characterized the complete genome of a novel dog circovirus (DogCV) from the liver of a dog with severe hemorrhagic gastroenteritis, vasculitis, and granulomatous lymphadenitis. DogCV was detected by PCR in fecal samples from 19/168 (11.3%) dogs with diarrhea and 14/204 (6.9%) healthy dogs and in blood from 19/409 (3.3%) of dogs with thrombocytopenia and neutropenia, fever of unknown origin, or past tick bite. Co-infection with other canine pathogens was detected for 13/19 (68%) DogCV-positive dogs with diarrhea. DogCV capsid proteins from different dogs varied by up to 8%. In situ hybridization and transmission electron microscopy detected DogCV in the lymph nodes and spleens of 4 dogs with vascular compromise and histiocytic inflammation. The detection of a circovirus in tissues of dogs expands the known tropism of these viruses to a second mammalian host. Our results indicate that circovirus, alone or in co-infection with other pathogens, might contribute to illness and death in dogs.
-
Subjects:
-
Source:
-
Document Type:
-
Place as Subject:
-
Location:
-
Volume:19
-
Issue:4
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type: