Nifedipine Pretreatment Reduces Vibration-Induced Vascular Damage

Details

• Personal Author:
  Bain JL ; Curry BD ; Govindaraju SR ; Matloub, Hani S. ; Riley, Danny A. ; Yan JG ; Zhang LL
• Description:
  A rat-tail vibration model of hand-arm vibration was employed to test whether preemptive administration of nifedipine (5 mg/kg) to block vasoconstriction prevents vibration-induced arterial damage. The tails of vibrated and nifedipine-pretreated vibrated Sprague-Dawley rats were exposed continuously to 4 h of 60-HZ vibration at 49 m/s(2) rms. In nonvibrated anesthetized rats, the ventral tail arteries were bathed for 15 min in situ in 1 mM epinephrine or 1 mM norepinephrine to induce structural changes indicative of intense vasoconstriction. Arteries were processed for light and electron microscopy 45 min after treatment. Compared to sham control, 4-h vibration significantly (P < 0.01) reduced lumen size, generated endothelial disruption (7.0 +/- 2.6%), elevated nuclear factor of activated T cells c3 (NFATc3) expression in endothelial and smooth muscle cells, and increased smooth muscle cell vacuolization. The findings demonstrate that blockage of vibration-induced vasoconstriction with nifedipine prevents acute vascular damage. Smooth muscle and endothelial cells structurally altered by vasoconstriction are rendered susceptible to damage by vibration. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Monitoring Laboratories Musculoskeletal System Nervous System Nervous System Diseases Occupational Health Safety Vibration
• Keywords:
  Animal-studies Arm-injuries Exposure-assessment Exposure-levels Hand-injuries Laboratory-animals Neurovascular-disorders Vibration-effects Vibration-exposure
• ISSN:
  0148-639X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  32
• Issue:
  5
• NIOSHTIC Number:
  nn:20028790
• Citation:
  Muscle Nerve 2005 Nov; 32(5):639-646
• Contact Point Address:
  Danny A. Riley, Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
• Email:
  dariley@mcw.edu
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  Medical College of Wisconsin, Milwaukee, Wisconsin
• Peer Reviewed:
  True
• Start Date:
  19990901
• Source Full Name:
  Muscle & Nerve
• End Date:
  20160831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d586a71ab4fffa639e1fcd8bfa11a4a7c95ef6bfd1e1c2eba7c7bc1e09f06fdd9dcb759e0aa26365dda94febe5a268a98fe2aa1aca137c6963f216d6ad4bf390
• Download URL:
  https://stacks.cdc.gov/view/cdc/189918/cdc_189918_DS1.pdf
• File Type:
  [PDF - 540.96 KB ]