Characterization of Frequency-Dependent Responses of the Vascular System to Repetitive Vibration

Details

• Personal Author:
  Johnson C ; Kashon ML ; Krajnak, Kristine M. ; Li S ; Miller, G. Roger ; Waugh, Stacey
• Description:
  OBJECTIVE: The current frequency weighting proposed in the International Standards oganization-5349 standard may underestimate the risk of injury associated with exposure to vibration >100 Hz. The goal of this study was to assess the frequency-dependent responses of the peripheral vascular system to repeated bouts of vibration. METHODS: The effects of exposure to vibration at 62.5, 125, or 250 Hz (constant acceleration of 49 m/s2) on vascular morphology, oxidative stress, inflammation, and gene expression were examined in the ventral tail artery of rats. RESULTS: Vascular responses indicative of dysfunction (eg, remodeling and oxidative activity) became more pronounced as the frequency of the exposure increased. CONCLUSION: Exposure to vibration frequencies that induce the greatest stress and strain on the tail (ie, >100 Hz) result in vascular changes indicative of dysfunction. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Monitoring Genetics Laboratories Nervous System Nervous System Diseases Occupational Health Safety Vibration
• Keywords:
  Animal-studies Exposure-assessment Exposure-levels Genes Laboratory-animals Laboratory-testing Morphology Neurovascular-disorders Oxidative-processes Peripheral-nervous-system Standards Vibration-effects Vibration-exposure

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• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  52
• Issue:
  6
• NIOSHTIC Number:
  nn:20036968
• Citation:
  J Occup Environ Med 2010 Jun; 52(6):584-594
• Contact Point Address:
  Kristine Krajnak, PhD, Biostatics and Epidemiology Branch, NIOSH, 1095 Willowdale Road, MS2027, Morgantown, WV 26505
• Email:
  ksk1@cdc.gov
• Federal Fiscal Year:
  2010
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0f2228a4aac3162d4d36f1f296b30c066f971b07c667896cccb0b78e9c46621e717b91f59ab6274e159b9fb4e2c6e9dbd771bb4203c22aaf8d60702823237ac7
• Download URL:
  https://stacks.cdc.gov/view/cdc/188163/cdc_188163_DS1.pdf
• File Type:
  [PDF - 1.50 MB ]