Treatment Outcomes for Extensively Drug-Resistant Tuberculosis and HIV Co-infection

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  O’Donnell, Max R. ; Padayatchi, Nesri ; Kvasnovsky, Charlotte ; Werner, Lise ; Master, Iqbal ; Horsburgh, C. Robert
• Description:
  High mortality rates have been reported for patients co-infected with extensively drug-resistant tuberculosis (XDR-TB) and HIV, but treatment outcomes have not been reported. We report treatment outcomes for adult XDR TB patients in KwaZulu-Natal Province, South Africa. Initial data were obtained retrospectively, and outcomes were obtained prospectively during 24 months of treatment. A total of 114 XDR TB patients were treated (median 6 drugs, range 3-9 drugs); 82 (73%) were HIV positive and 50 (61%) were receiving antiretroviral therapy. After receiving treatment for 24 months, 48 (42%) of 114 patients died, 25 (22%) were cured or successfully completed treatment, 19 (17%) withdrew from the study, and 22 (19%) showed treatment failure. A higher number of deaths occurred among HIV-positive patients not receiving antiretroviral therapy and among patients who did not show sputum culture conversion. Culture conversion was a major predictor of survival but was poorly predictive (51%) of successful treatment outcome.
• Subjects:
  Adolescent Adult Antitubercular Agents Bacteria Co-infection Coinfection Cycloserine Drug Therapy, Combination Ethambutol Ethionamide Extensively Drug-resistant Tuberculosis Female HIV HIV Infections Humans Kaplan-Meier Estimate Male Middle Aged Pyrazinamide Research Retrospective Studies Treatment Outcome Treatment Outcomes Tuberculosis, Pulmonary Tuberculosis And Other Mycobacteria Viruses XDR TB Young Adult

  More +
• Source:
  Emerg Infect Dis. 19(3):416-424.
• Document Type:
  Journal Article
• Place as Subject:
  South Africa
• Location:
  Africa
• Volume:
  19
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4a2e0f18a37ec172791cd21dec56167651423b0ae9482ae539488dad9d66ba61
• Download URL:
  https://stacks.cdc.gov/view/cdc/18935/cdc_18935_DS1.pdf
• File Type:
  [PDF - 477.02 KB ]