Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
O’Donnell, Max R. ; Padayatchi, Nesri ; Kvasnovsky, Charlotte ; Werner, Lise ; Master, Iqbal ; ... More +
O’Donnell, Max R. ; Padayatchi, Nesri ; Kvasnovsky, Charlotte ; Werner, Lise ; Master, Iqbal ; Horsburgh, C. Robert Less -
Description:
High mortality rates have been reported for patients co-infected with extensively drug-resistant tuberculosis (XDR-TB) and HIV, but treatment outcomes have not been reported. We report treatment outcomes for adult XDR TB patients in KwaZulu-Natal Province, South Africa. Initial data were obtained retrospectively, and outcomes were obtained prospectively during 24 months of treatment. A total of 114 XDR TB patients were treated (median 6 drugs, range 3-9 drugs); 82 (73%) were HIV positive and 50 (61%) were receiving antiretroviral therapy. After receiving treatment for 24 months, 48 (42%) of 114 patients died, 25 (22%) were cured or successfully completed treatment, 19 (17%) withdrew from the study, and 22 (19%) showed treatment failure. A higher number of deaths occurred among HIV-positive patients not receiving antiretroviral therapy and among patients who did not show sputum culture conversion. Culture conversion was a major predictor of survival but was poorly predictive (51%) of successful treatment outcome.
Subject:
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Adolescent
Adult
Antitubercular Agents
Bacteria
Co-infection
Coinfection
Cycloserine
Drug Therapy, Combination
Ethambutol
Ethionamide
Extensively Drug-resistant Tuberculosis
Female
HIV
HIV Infections
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Pyrazinamide
Research
Retrospective Studies
Treatment Outcome
Treatment Outcomes
Tuberculosis, Pulmonary
Tuberculosis And Other Mycobacteria
Viruses
XDR TB
Young Adult

Source:
Emerg Infect Dis. 19(3):416-424.
Document Type:
Journal Article
Place as Subject:
South Africa
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:4a2e0f18a37ec172791cd21dec56167651423b0ae9482ae539488dad9d66ba61
File Type:

Supporting Files

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