Efficacy of Taurine Based Compounds as Hydroxyl Radical Scavengers in Silica Induced Peroxidation

Details

• Personal Author:
  Castranova, Vincent ; Flynn DC ; Leonard, Stephen S. ; Porter DW ; Shi X ; Vallyathan V
• Description:
  While it is widely believed that taurine may play an important role in protecting cells against toxic injury by functioning as an antioxidant, there is a lack of evidence to support this hypothesis. In this study, electron spin resonance (ESR) was used to investigate the reaction of taurine and hypotaurine with hydroxyl radicals (.OH). The Fenton reaction (Fe(II) + H2O2-->Fe(III) + .OH + OH-) and the Cr(V)-mediated Fenton-like reaction (Cr(V) + H2O2-->Cr(VI) + .OH + OH-) were used as sources of .OH radicals. The results show that hypotaurine but not taurine effectively scavenges .OH radicals with a reaction rate constant of k = 1.6 x 10(10) M-1s-1. That is comparable with other efficient .OH radical scavengers. The effect of taurine and hypotaurine on silica-induced lipid peroxidation was evaluated using linoleic acid as a model lipid. Hypotaurine, but not taurine, caused a significant inhibition of silica-induced lipid peroxidation. The results show that hypotaurine is an excellent antioxidant and appears to have the potential for being a therapeutic agent against silica-induced lung injury. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Antioxidants Free Radicals Irritants Lipids Lung Occupational Health Respiratory System Safety
• Keywords:
  Cell-biology Cell-damage Cell-function Cellular-reactions Free-radical-generation Free-radicals Lipid-peroxidation Lung-irritants Respiratory-irritants Silicates
• ISSN:
  0091-7370
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  365-374
• Volume:
  27
• Issue:
  5
• NIOSHTIC Number:
  nn:20033929
• Citation:
  Ann Clin Lab Sci 1997 Sep; 27(5):365-374
• Contact Point Address:
  Xianglin Shi, Ph.D., Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mail Stop L2015, Morgantown, WV 26505
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7) ; Taurine (CAS RN 107-35-7)
• Federal Fiscal Year:
  1997
• Peer Reviewed:
  True
• Source Full Name:
  Annals of Clinical and Laboratory Science
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9300452b5f725ad19ce1df5aa67b3e6802084b251156b657df372d2b48220603c058f97f294ba4bdeec559580fd17bb90a7ccf3a71eaa73181c2bff50c1b69fd
• Download URL:
  https://stacks.cdc.gov/view/cdc/189328/cdc_189328_DS1.pdf
• File Type:
  [PDF - 1.61 MB ]