Oxidative Stress, Pulmonary Toxicity and Progressive Fibrosis Induced by Exposure to Single-Walled Carbon Nanotubes

Details

• Personal Author:
  Kagan VE ; Shvedova AA ; Kagan VE ; Shvedova AA
• Description:
  Nanotechnology is a fast growing field with emerging development of modern materials for electronics and information technology industries, cosmetics, health and medicine and in a variety of manufactured goods. Single-Walled Carbon Nanotubes (SWCNT) with unique physico-chemical, electronic and mechanical properties are novel materials of technological importance. Pulmonary exposure to SWCNT revealed toxicity within the range of doses relevant to exposure limits established by regulatory agencies for fine size carbon particles. In C57BL/6 mice exposed to SWCNT, pulmonary toxicity was associated with a dose-dependent augmentation of biomarkers of cell injury and oxidative stress quantified by cell counts, total protein, lactate dehydrogenase and g-glutamyltranspeptidase activities, reduced level of GSH, total antioxidant reserve along with the accumulation of lipid peroxidation products found in bronchoalveolar lavage (BAL) fluid and in the lung. Markers of pulmonary cytotoxicity corresponded to early development of acute inflammation, collagen accumulation, and progressive fibrosis. In mice maintained on vitamin E deficient diet, SWCNT significantly enhanced collagen deposition as compared to the vitamin E sufficient group. Overall, our data suggest that pharyngeal aspiration of SWCNT elicited a robust acute inflammatory response with early onset of progressive pulmonary fibrosis whose expression and severity was associated with the intensity of oxidative stress in the lung of the exposed C57BL/6 mice. [Description provided by NIOSH]
• Subjects:
  Irritants Laboratories Lung Lung Diseases Occupational Health Particulate Matter Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Laboratory-animals Lung-cells Lung-disorders Lung-fibrosis Lung-irritants Nanotechnology Particle-aerodynamics Particulate-dust Particulates Pulmonary-congestion Pulmonary-disorders Pulmonary-system Pulmonary-system-disorders Respiration Respiratory-hypersensitivity Respiratory-irritants Respiratory-rate Respiratory-system-disorders

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• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary ; Proceedings ; Abstract or Summary ; Proceedings
• Place as Subject:
  OSHA Region 10 ; OSHA Region 3 ; Pennsylvania ; Washington ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  62
• NIOSHTIC Number:
  nn:20033683
• Citation:
  Free Radicals in Montevideo, Montevideo, Uruguay, September 2-6, 2007. Montevideo, Uruguay: The Center for Free Radical and Biomedical Research - Uruguay, 2007 Sep; :62
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0) ; Carbon (CAS RN 7440-44-0)
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Manufacturing ; Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Free Radicals in Montevideo, September 2-6, 2007, Montevideo, Uruguay
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4fe6b899f12df60a5466dd6bf9c54eb60b806eb2302ff4f8d72156c2c8b691c0539bc692572518495265e137bfaf7b7f12c296921a385a2c01e99c1733685861
• Download URL:
  https://stacks.cdc.gov/view/cdc/189162/cdc_189162_DS1.pdf
• File Type:
  [PDF - 277.30 KB ]