Transmission Routes for Nipah Virus from Malaysia and Bangladesh

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Clayton, Bronwyn A. ; Middleton, Deborah ; Bergfeld, Jemma ; Haining, Jessica ; Arkinstall, Rachel ; Wang, Linfa ; Marsh, Glenn A.
• Description:
  Human infections with Nipah virus in Malaysia and Bangladesh are associated with markedly different patterns of transmission and pathogenicity. To compare the 2 strains, we conducted an in vivo study in which 2 groups of ferrets were oronasally exposed to either the Malaysia or Bangladesh strain of Nipah virus. Viral shedding and tissue tropism were compared between the 2 groups. Over the course of infection, significantly higher levels of viral RNA were recovered from oral secretions of ferrets infected with the Bangladesh strain. Higher levels of oral shedding of the Bangladesh strain of Nipah virus might be a key factor in onward transmission in outbreaks among humans.
• Subjects:
  Animals Antigens, Viral Choroid Plexus Disease Models, Animal Endothelial Cells Endothelium Ependyma Ferrets Henipavirus Infections Humans Male Neurons Nipah Virus Palatine Tonsil Research Viral Load Virus Shedding

  More +
• Source:
  Emerg Infect Dis. 18(12):1983-1993.
• Document Type:
  Journal Article
• Place as Subject:
  Bangladesh ; Malaysia
• Location:
  Asia
• Volume:
  18
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:05266b522c6be6bcd325233b9d89953d097ee7512e53a98f409b96f484d5fa89
• Download URL:
  https://stacks.cdc.gov/view/cdc/18913/cdc_18913_DS1.pdf
• File Type:
  [PDF - 642.87 KB ]