The Localization of Vascular Endothelial Growth Factor in a Repetitively Loaded Tendon In Vivo: An Immunohistological Study

Details

• Personal Author:
  King KB ; Nakama LH ; Rempel DM
• Description:
  Vascular Endothelial Growth Factor (VEGF) is one of the most important angiogenic components of tissue healing. In vitro and in vivo studies have shown that VEGF is responsible for stimulating the proliferation of microvascular endothelial cells, inducing angiogenesis and rendering the microvasculature hyperpermeable. In the tendon, expression of VEGF can be up-regulated by both mechanical and biochemical stimuli that includes hypoxia and the presence of other growth factors. Recent studies have shown that in the injured tendon, the highest levels of VEGF occur after inflammation when it acts as a potent stimulator of angiogenesis. The ingrowth of new blood vessels towards the repair site from within the healing tendon appears necessary for healing to occur. Currently, little is known about the role that VEGF and other growth factors play in tendon loading and injury. Elucidating the cellular and molecular pathways that occur during this period may lead to a better understanding of mechanisms behind tendon healing and remodeling. Our laboratory has developed a rabbit model of epicondylitis in which the flexor digitorum profundus (FDP) muscle is repeatedly stimulated against a load. The purpose of this study was to evaluate the regional variation of VEGF staining cells in the FDP tendon at the epicondyle in response to repetitive loading. [Description provided by NIOSH]
• Subjects:
  Animals Biomechanical Phenomena Cumulative Trauma Disorders Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Animal-studies Biomechanics Cumulative-trauma Cumulative-trauma-disorders In-vivo-studies Injuries Laboratory-animals Models Muscles Musculoskeletal-system Musculoskeletal-system-disorders Repetitive-work

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• ISSN:
  0149-6433
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  50
• NIOSHTIC Number:
  nn:20033289
• Citation:
  Trans Annu Meet Orthop Res Soc 2004 Mar; 50:0860
• Contact Point Address:
  University of California, 1301 South 46th Street. Building 163, Richmond, CA 94804
• Federal Fiscal Year:
  2004
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  University of California - San Francisco
• Peer Reviewed:
  False
• Start Date:
  20010701
• Source Full Name:
  Transactions of the Annual Meeting of the Orthopaedic Research Society
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:005dedbaab6d14819f82ed21abc3227d6128b451bc71dc830d20d61fcf4de67f5dc5e93f016b85e79655b6e781dab6d070923ad012158516845fc5b9e0f38426
• Download URL:
  https://stacks.cdc.gov/view/cdc/188931/cdc_188931_DS1.pdf
• File Type:
  [PDF - 90.87 KB ]