Cyclical in vivo loading increases cartilage proteoglycan content in the rabbit metacarpophalangeal joint

Details

• Personal Author:
  Burghardt A ; King KB ; Majumdar S ; Saadat E
• Description:
  The composition of the extracellular matrix of cartilage dictates its mechanical properties. Proteoglycans (PG) and collagen are two important structural components of the cartilage extracellular matrix. The ability to measure changes both in the amount and distribution of cartilage matrix constituents is essential in understanding early pathological changes of joint diseases. Previous studies have examined the biosynthetic response of articular cartilage with cyclical loading of osteochondral explants in vitro. We have developed a novel method of repetitive joint flexion and loading to examine the biosynthetic response of cyclical loading in vivo. This study examines the change in the amounts of proteoglycans and collagen in articular cartilage resulting from in vivo cyclical loading using Fourier transform infrared (FTIR) imaging spectroscopy. [Description provided by NIOSH]
• Subjects:
  Animals Biomechanical Phenomena Cumulative Trauma Disorders Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Animal-studies Biomechanics Cumulative-trauma Cumulative-trauma-disorders In-vivo-studies Injuries Laboratory-animals Models Muscles Musculoskeletal-system-disorders Repetitive-work

  More +
• ISSN:
  0149-6433
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  California ; Colorado ; OSHA Region 8 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  52
• NIOSHTIC Number:
  nn:20038588
• Citation:
  Trans Annu Meet Orthop Res Soc 2006 Mar; 52:1352
• Email:
  kbking@itsa.ucsf.edu
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  University of California - San Francisco
• Peer Reviewed:
  False
• Start Date:
  20010701
• Source Full Name:
  Transactions of the Annual Meeting of the Orthopaedic Research Society
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8abbacc62f4ba055f9e7bd65878ae46d543bd8a295321b27b4da296f9815e48ffa35a27d6d5a2d9433c5251aa260ede1cc0d247cfa9337733c02b605976ca3f4
• Download URL:
  https://stacks.cdc.gov/view/cdc/192241/cdc_192241_DS1.pdf
• File Type:
  [PDF - 21.25 KB ]