An In Vivo Model for Entrapment Neuropathy Due to Repeated Finger Loading

Details

• Personal Author:
  Abrahmsson S ; Dahlin LB ; King K ; Rempel D ; Robertsson J
• Description:
  Carpal tunnel syndrome is the most common entrapment neuropathy and accounts for high levels of disability in the workplace. Carpal tunnel syndrome may be caused by repetitive, forceful fingertip loading; however, the mechanisms of injury and the relationships between force-duration and injury are not fully known. Knowledge of the injurious mechanical factors (e.g., load rate, number of repetition cycles, peak load, etc.) would be useful in developing primary and secondary preventive measures. However, these mechanistic details will primarily emerge with the development of an appropriate animal model. The purpose of this study was to develop and validate a rabbit model of median neuropathy at the wrist due to repetitive loading of the flexor digitorum profundus (FDP) muscle. The rabbit forearm, carpal tunnel, fingers and nerve anatomy are roughly similar to the human. [Description provided by NIOSH]
• Subjects:
  Animals Biomechanical Phenomena Cumulative Trauma Disorders Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Animal-studies Biomechanics Carpal-tunnel-syndrome Cumulative-trauma Cumulative-trauma-disorders In-vivo-studies Injuries Laboratory-animals Models Muscles Musculoskeletal-system Musculoskeletal-system-disorders Repetitive-work Tissue-disorders

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• ISSN:
  0149-6433
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  47
• NIOSHTIC Number:
  nn:20033287
• Citation:
  Trans Annu Meet Orthop Res Soc 2001 Feb; 47:0734
• Email:
  rempel@itsa.ucsf.edu
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  University of California - San Francisco
• Peer Reviewed:
  False
• Start Date:
  20010701
• Source Full Name:
  Transactions of the Annual Meeting of the Orthopaedic Research Society
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a3bd9b3563f35d45115fee3f41660b81cc05437178f131b63863e8a1e546a22024d8fcd6cf651953ad64c7ef1bd1a0752d657b961682834865d51f73e4f356e8
• Download URL:
  https://stacks.cdc.gov/view/cdc/188929/cdc_188929_DS1.pdf
• File Type:
  [PDF - 70.63 KB ]