The Localization of Connective Tissue Growth Factor in a Cyclically Loaded Tendon at the Epicondyle in an In Vivo Model of Tendinosis

Details

• Personal Author:
  King KB ; Nakama LH ; Rempel DM
• Description:
  Connective Tissue Growth Factor (CTGF) has recently been investigated in wound healing and scar formation studies. Its role in the pathology of tendon overuse injuries has not yet been investigated. CTGF is a cysteine-rich secretory protein and belongs to a six member family who are known to be involved in fundamental biological processes such as cell proliferation, attachment, migration, differentiation, wound healing and angiogenesis as well as in the development of several pathologic conditions including fibrosis and tumorigenesis. CTGF has been identified as a potent inducer of extracellular matrix synthesis and is up-regulated by tensile stresses. Soft tissue injuries are common in athletes and workers whose job functions require repetitive and forceful hand activities. The mechanism leading to tendinosis is not well known but likely involves microtears and an inflammatory response. The purpose of this study was to evaluate the effects of in vivo cyclical digit loading on CTGF- positive staining cell density in the Flexor Digitorum Profundus (FDP) tendon at the epicondyle. [Description provided by NIOSH]
• Subjects:
  Animals Biomechanical Phenomena Cumulative Trauma Disorders Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Animal-studies Biomechanics Cumulative-trauma Cumulative-trauma-disorders In-vivo-studies Injuries Laboratory-animals Models Muscles Musculoskeletal-system Musculoskeletal-system-disorders Repetitive-work Tissue-disorders

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• ISSN:
  0149-6433
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  51
• NIOSHTIC Number:
  nn:20033286
• Citation:
  Trans Annu Meet Orthop Res Soc 2005 Mar; 51:0762
• Email:
  drempel@itsa.ucsf.edu
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  University of California - San Francisco
• Peer Reviewed:
  False
• Start Date:
  20010701
• Source Full Name:
  Transactions of the Annual Meeting of the Orthopaedic Research Society
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9b540679c08ac540301adb64bf65814a83b0196d6e3c7d246068a478c5af490be84c94a0432305e79c47fdf38b770ea5db94157c143fe525ae06bf4c40ff00d6
• Download URL:
  https://stacks.cdc.gov/view/cdc/188928/cdc_188928_DS1.pdf
• File Type:
  [PDF - 37.85 KB ]