Delivery Methods for Peptide and Protein Toxins in Insect Control

Details

• Personal Author:
  Hammock BD ; Whetstone PA
• Description:
  Since the introduction of DDT in the 1940s, arthropod pest control has relied heavily upon chemical insecticides. However, the development of insect resistance, an increased awareness of the real and perceived environmental and health impacts of these chemicals, and the need for systems with a smaller environmental footprint has stimulated the search for new insecticidal compounds, novel molecular targets, and alternative control methods. In recent decades a variety of biocontrol methods employing peptidic or proteinaceous insect-specific toxins derived from microbes, plants and animals have been examined in the laboratory and field with varying results. Among the many interdependent factors involved with the production of a cost-effective pesticide--production expense, kill efficiency, environmental persistence, pest-specificity, pest resistance-development, public perception and ease of delivery--sprayable biopesticides have not yet found equal competitive footing with chemical counterparts. However, while protein/peptide-based biopesticides continue to have limitations, advances in the technology, particularly of genetically modified organisms as biopesticidal delivery systems, has continually progressed. This review highlights the varieties of delivery methods currently practiced, examining the strengths and weaknesses of each method. [Description provided by NIOSH]
• Subjects:
  Animals Atmosphere Biological Factors Biological Warfare Agents Chemistry Environment Environmental Exposure Environmental Health Environmental Monitoring Environmental Pollution Hazardous Substances Insecticides Occupational Health Safety

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• Keywords:
  Animal-products Animal-studies Atmosphere-analyzers Biohazards Biological-factors Biological-monitoring Biological-warfare-agents Chemical-analysis Control-methods Control-systems Environmental-control Environmental-exposure Environmental-factors Environmental-hazards Environmental-health Environmental-pollution Environmental-protection Pest-control Pesticide-industry Pesticide-residues Pesticides Pests Protein-biochemistry Protein-biosynthesis Protein-chemistry Protein-synthesis Proteins Toxic-effects Toxic-materials Toxic-vapors Toxins

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• ISSN:
  0041-0101
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  49
• Issue:
  4
• NIOSHTIC Number:
  nn:20033211
• Citation:
  Toxicon 2007 Mar; 49(4):576-596
• Contact Point Address:
  P. A. Whetstone, Bayer Healthcare, Quality Control Unit, Berkeley, CA 94701
• Federal Fiscal Year:
  2007
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Toxicon
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6d9ee1d4580f42be0752fdc11d84d7c73278001a8614d65b0792bad31ceeaba4e517b6a97f2c1ee5c735bcce4f3b53cd8020ba43400ff433acab7b1b4d161821
• Download URL:
  https://stacks.cdc.gov/view/cdc/188877/cdc_188877_DS1.pdf
• File Type:
  [PDF - 328.04 KB ]