Monitoring Method for Surface Contamination Caused by Selected Antineoplastic Agents

Details

• Personal Author:
  Dillon HK ; Khazaeli MB ; Larson RR
• Description:
  A method of evaluating surface contamination caused by selected antineoplastic agents was studied. The antineoplastic agents tested were cyclophosphamide, ifosfamide, doxorubicin hydrochloride, fluorouracil, and paclitaxel. Each agent was reconstituted and prepared as a stock solution. A 0.1-mL portion of each solution was spread evenly over a 600-cm2 area of a stainless steel surface, a resin countertop surface, and a vinyl flooring surface. After drying, the surfaces were wiped with each of two types of commercially available wiping materials (What-man no. 42 filters and Kimberly-Clark Kimwipes). A blend of methanol, acetonitrile, and buffered water was used both as the wetting agent for wiping the surfaces and as a desorbing solution. The desorbate was analyzed for drug concentration by reverse-phase high-performance liquid chromatography (HPLC). Mean +/- S.D. percent total recovery ranged from 72.4% +/- 17.6% to 95.3% +/- 2.9% for the vinyl surface wiped with filters, 91.5% +/- 5.4% to 104.7% +/- 0.8% for the resin surface wiped with filters, 73.9% +/- 2.3% to 95.3% +/- 1.7% for the stainless steel surface wiped with filters, and 18.2% +/- 1.4% to 372.8% +/- 8.0% for the stainless steel surface wiped with Kimwipes. Results were best for ifosfamide and cyclophosphamide. Kimwipes were deemed ineffective for this monitoring method because an ingredient interfered with the quantitative analytical tests. A wipe-sampling, desorption, and HPLC method for monitoring surface contamination by selected antineoplastic agents was sufficiently accurate and sensitive to evaluate surfaces typically found in both the pharmacy and drug administration areas of oncology treatment facilities. [Description provided by NIOSH]
• Subjects:
  Antineoplastic Agents Chromatography Epoxy Resins Occupational Health Safety Solvents Vinyl Chloride
• Keywords:
  Antineoplastic-agents Author Keywords: Antineoplastic Agents Contamination Cyclophosphamide Doxorubicin Hydrochloride Drugs Fluorouracil Ifosfamide Liquid Liquid-chromatography Methodology Oncogenic-agents Paclitaxel Resins Stainless-steel Surface-properties Tests Vinyl-plastics

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• ISSN:
  1079-2082
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; OSHA Region 4 ; OSHA Region 8 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  270-277
• Volume:
  59
• Issue:
  3
• NIOSHTIC Number:
  nn:20037556
• Citation:
  Am J Health Syst Pharm 2002 Feb; 59(3):270-277
• Contact Point Address:
  Dr. Larson at the Department of Environmental Health Sciences, School of Public Health, The University of Alabama at Birmingham, RPHB 317, 1530 3rd Avenue South, Birmingham, AL 35294-0022
• CAS Registry Number:
  5-Fluorouracil (CAS RN 51-21-8) ; Cyclophosphamide (CAS RN 50-18-0) ; Doxorubicin (CAS RN 23214-92-8) ; Ifosfamide (CAS RN 3778-73-2) ; Paclitaxel (CAS RN 33069-62-4)
• Federal Fiscal Year:
  2002
• Performing Organization:
  University of Utah
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Health-System Pharmacy
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3a784545b6550796ead4dedbb810a92ffbc0f5f4d232251f3850c6fb7c4285ee97ef365f200444e06a6294518023c8796de3fcf500c6396f25f438050def1996
• Download URL:
  https://stacks.cdc.gov/view/cdc/188632/cdc_188632_DS1.pdf
• File Type:
  [PDF - 171.05 KB ]