Pesticide Metabolism and Potential for Metabolic Interactions

Hodgson E; Rose LR

i

Pesticide Metabolism and Potential for Metabolic Interactions

2005/08/01
By Hodgson E ; Rose LR

Details

Personal Author:

Hodgson E ; Rose LR
Description:

Studies in whichhuman hepatocytes are exposed to varying concentrations of pesticides indicate that several pesticides are capable of inducing CYP enzymes. Chlorpyrifos, for example, induces isoforms CYP1A1, 1A2, 2B6, and 3A4 to levels five-fold or greater than controls. Permethrin, which was not metabolized in vitro by CYP isoforms, also induced CYP2A6, 2B6, and 3A4 [8]. The implications of the ability of pesticides to induce CYP isoforms in human hepatocytes will require further study; particularly to determine if concentrations necessary for such induction would occur in vivo. [Description provided by NIOSH]
Subjects:

Agriculture Animals Biopharmaceutics Chemical Warfare Agents Chemistry Digestive System Digestive System Diseases Energy Metabolism Environment Environmental Exposure Environmental Health Environmental Monitoring Environmental Pollution Enzymes Epidemiology Esters Hypersensitivity Insecticides Liver Livestock Neoplasms Occupational Health Organophosphates Safety Stress, Psychological Sulfides Sulfur Compounds
Keywords:

Agricultural-chemicals Agricultural-workers Chemical-analysis Chemical-composition Chemical-deposition Chemical-extraction Chemical-hypersensitivity Chemical-properties Chemical-reactions Chemical-synthesis Chemical-warfare-agents Contaminated-food Environmental-contamination Environmental-exposure Environmental-factors Environmental-hazards Environmental-health Environmental-health-monitoring Environmental-pollution Environmental-protection Environmental-stress Enzymatic-disorders Enzymatic-effects Enzyme-activity Enzyme-complexes Enzyme-inhibitors Enzymology Exposure-assessment Exposure-levels Exposure-limits Exposure-methods Humans Liver-cancer Liver-cells Liver-damage Liver-disorders Liver-enzymes Liver-function Liver-microsomal-enzymes Liver-microsomal-metabolism Liver-microsomes Liver-tissue Liver-tumors Mesothelial-cells Metabolic-disorders Metabolic-study Metabolism Organo-phosphorus-compounds Organo-phosphorus-pesticides Pesticide-industry Pesticide-residues Pesticide-strips Pesticides Pesticides-and-agricultural-chemicals Pharmaceuticals Pharmacology Sulfates Sulfhydryls Sulfites Sulfonamides Sulfonates Sulfoxides Sulfur-compounds Sulfur-oxides
ISSN:

1095-6670
Document Type:

Text
Funding:

Cooperative Agreement
Genre:

Journal Article
Place as Subject:

North Carolina ; OSHA Region 4
CIO:

National Institute for Occupational Safety and Health (NIOSH)
Topic:

Workplace Safety & Health
Location:

North America
Pages in Document:

276-277
Volume:

19
Issue:

4
NIOSHTIC Number:

nn:20037199
Citation:

J Biochem Mol Toxicol 2005 Aug; 19(4):276-277
Contact Point Address:

Randy L. Rose, Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695
Email:

randy_rose@ncsu.edu
CAS Registry Number:

Carbaryl (CAS RN 63-25-2) ; Chlorpyrifos (CAS RN 2921-88-2)
Federal Fiscal Year:

2005
Performing Organization:

East Carolina University
Peer Reviewed:

False
Start Date:

20010930
Source Full Name:

Journal of Biochemical and Molecular Toxicology
End Date:

20080929
Collection(s):

National Institute for Occupational Safety and Health
Main Document Checksum:

urn:sha-512:5b3372fb279e61bc79de87732c4c183ca6616711aac8d8de066b8bc565bb9d8d79e8b4da1aaba4cea23834e0dbd6a5ccb1126718008f11e5b13dcf074080d27c
Download URL:

https://stacks.cdc.gov/view/cdc/188329/cdc_188329_DS1.pdf
File Type:

[PDF - 33.31 KB ]

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