Organophosphorus Chemicals: Potent Inhibitors of the Human Metabolism of Steroid Hormones and Xenobiotics

Hodgson E; Rose RL

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Organophosphorus Chemicals: Potent Inhibitors of the Human Metabolism of Steroid Hormones and Xenobiotics

2006/01/01
By Hodgson E ; Rose RL

Details

Personal Author:

Hodgson E ; Rose RL
Description:

Although it has been known for some time that organophosphate chemicals containing the P = S moiety are irreversible inhibitors of cytochrome P450, this knowledge has not been generally applied to the human metabolism of xenobiotics. Recent studies have demonstrated that organophosphate insecticides containing this moiety are potent inhibitors of the metabolism of both xenobiotics and endogenous substrates by human liver microsomes and by specific human cytochrome P450 isoforms. [Description provided by NIOSH]
Subjects:

Agriculture Animals Chemical Warfare Agents Chemistry Digestive System Digestive System Diseases Environmental Exposure Environmental Health Environmental Monitoring Environmental Pollution Hazardous Substances Hypersensitivity Insecticides Liver Microbiology Nitrogen Compounds Occupational Health Organophosphates Public Health Safety Workplace
Keywords:

Agricultural-chemicals Agricultural-workers Animal-studies Author Keywords: Carbaryl Chemical-analysis Chemical-binding Chemical-composition Chemical-hypersensitivity Chemical-indicators Chemical-reactions Chemical-structure Chemical-synthesis Chemical-warfare-agents Chlorpyrifos Chlorpyrifos Oxon CYP Cytochrome P450 DEET Environmental-exposure Environmental-factors Environmental-hazards Environmental-health Environmental-health-monitoring Environmental-pollution Estradiol Exposure-assessment Exposure-levels Exposure-limits Health-hazards Health-protection Health-standards Human CYP Isoforms Human Liver Microsomes Humans Insecticide-poisoning Liver-damage Liver-disorders Liver-enzymes Liver-function Liver-tissue Microchemistry Microsomal-enzymes Organic-chemicals Organo-nitrogen-compounds Organo-phosphorus-compounds Organo-phosphorus-pesticides Organophosphorus Insecticides Permethrin Pesticide-residues Pesticides Pesticides-and-agricultural-chemicals Public-health Testosterone Work-analysis Work-environment Worker-health Workplace-monitoring Workplace-studies
ISSN:

0360-2532
Document Type:

Text
Funding:

Cooperative Agreement
Genre:

Journal Article
Place as Subject:

North Carolina ; OSHA Region 4
CIO:

National Institute for Occupational Safety and Health (NIOSH)
Topic:

Workplace Safety & Health
Location:

North America
Pages in Document:

149-162
Volume:

38
Issue:

1
NIOSHTIC Number:

nn:20037175
Citation:

Drug Metab Rev 2006 Jan; 38(1-2):149-162
Contact Point Address:

Ernest Hodgson, Department of Environmental and Molecular Toxicology, Box 7633, North Carolina State University, Raleigh, NC 27695, USA
Email:

ernest_hodgson@ncsu.edu
CAS Registry Number:

Carbaryl (CAS RN 63-25-2) ; Permethrin (CAS RN 52645-53-1)
Federal Fiscal Year:

2006
Performing Organization:

East Carolina University
Peer Reviewed:

True
Start Date:

20010930
Source Full Name:

Drug Metabolism Reviews
End Date:

20080929
Collection(s):

National Institute for Occupational Safety and Health
Main Document Checksum:

urn:sha-512:a136220d5032502059b7d08a233edef307b3ee263e56d33367b734de678b19d7b7690bfdad6525441c5d174e4a374cc10809d209ec44c8ae6c6d97f0d50b611e
Download URL:

https://stacks.cdc.gov/view/cdc/188308/cdc_188308_DS1.pdf
File Type:

[PDF - 146.52 KB ]

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