Toxicology of AHS Important Chemicals

Hudgson E; Rose LR

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Toxicology of AHS Important Chemicals

2005/06/01
By Hudgson E ; Rose LR

Details

Personal Author:

Hudgson E ; Rose LR
Description:

The chloroacetamide herbicides, alachlor., acetochlor butachlor and metolachlor. have been associated with cancers at various sites in rodents as follows: acetochlor.nasal epithelium, thyroid, liver; butachlor.stomach; alachlor.nasal epithelium, thyroid, stomach; metolachlor.liver. The DNA reactive intermediates are quinone imines generated by metabolic pathways that involve CYP isoforms as well as arylamidase. However, since the metabolism of these chemicals varies between rodents and humans, it is not clear how these results may be extrapolated to humans. Although little is known about the metabolism of the substituted aromatic herbicides dicamba and pendimethalin in humans or surrogate animals, they are of low acute toxicity tomammalsand not previously known to be carcinogenic. However, early results from the AHS associate these chemicals with lung cancer. [Description provided by NIOSH]
Subjects:

Agriculture Animals Blood Chemical Warfare Agents Chemistry Chronic Disease Energy Metabolism Environment Environmental Exposure Environmental Health Environmental Monitoring Environmental Pollution Hazardous Substances Hematologic Tests Hypersensitivity Insecticides Kidney Diseases Manufacturing And Industrial Facilities Nervous System Nervous System Diseases Nitrogen Compounds Occupational Exposure Occupational Health Organophosphates Safety Stress, Psychological Toxicology Urogenital Diseases Urogenital System
Keywords:

Acute-exposure Acute-toxicity Agricultural-chemicals Agricultural-industry Agricultural-machinery Agricultural-processes Agricultural-products Agricultural-workers Blood-samples Blood-sampling Chemical-composition Chemical-deposition Chemical-extraction Chemical-factory-workers Chemical-hypersensitivity Chemical-indicators Chemical-processing Chemical-properties Chemical-reactions Chemical-structure Chemical-synthesis Chemical-warfare-agents Chronic-degenerative-diseases Chronic-exposure Chronic-inflammation Chronic-toxicity Environmental-exposure Environmental-factors Environmental-hazards Environmental-health Environmental-health-monitoring Environmental-pollution Environmental-protection Environmental-stress Health-hazards Health-standards Humans Mesothelial-cells Metabolic-disorders Metabolic-study Metabolism Metabolites Nephrological-disorders Nephrotoxicity Nephrotoxins Nerve-damage Neurohormones Neurological-diseases Neurological-reactions Neurological-system Neuromotor-disorders Neuromotor-function Neuromotor-system Neuromotor-system-disorders Neuromuscular-function Neuromuscular-system Neuromuscular-system-disorders Neuropathology Neuropathy Neurophysiological-effects Neurophysiology Neurotoxic-effects Neurotoxicity Neurotoxicology Neurotoxins Organo-nitrogen-compounds Organo-phosphorus-compounds Organo-phosphorus-pesticides Pesticide-industry Pesticide-residues Pesticide-strips Pesticides Pesticides-and-agricultural-chemicals Toxic-effects Toxic-gases Toxic-vapors Toxicopathology Toxins Trace-analysis
ISSN:

1095-6670
Document Type:

Text
Funding:

Cooperative Agreement
Genre:

Journal Article
Place as Subject:

North Carolina ; OSHA Region 4
CIO:

National Institute for Occupational Safety and Health (NIOSH)
Topic:

Workplace Safety & Health
Location:

North America
Pages in Document:

180-181
Volume:

19
Issue:

3
NIOSHTIC Number:

nn:20037197
Citation:

J Biochem Mol Toxicol 2005 Jun; 19(3):180-181
Contact Point Address:

Ernest Hodgson, Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh NC 27695, USA
Email:

ernest-hodgson@ncsu.edu
CAS Registry Number:

Carbaryl (CAS RN 63-25-2) ; Chlorpyrifos (CAS RN 2921-88-2) ; Diazinon (CAS RN 333-41-5)
Federal Fiscal Year:

2005
Performing Organization:

East Carolina University
Peer Reviewed:

False
Start Date:

20010930
Source Full Name:

Journal of Biochemical and Molecular Toxicology
End Date:

20080929
Collection(s):

National Institute for Occupational Safety and Health
Main Document Checksum:

urn:sha-512:b5723844a987cc640d6922a19d75696f1ff9845d458965533c0103a17fe474acf03130e1fa870296885c7526be25d28c880c72fe0765137330384563a2d91cee
Download URL:

https://stacks.cdc.gov/view/cdc/188328/cdc_188328_DS1.pdf
File Type:

[PDF - 33.54 KB ]

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