Exposure Assessment [from: Identification of research needs to resolve the carcinogenicity of high-priority IARC Carcinogens]

Details

• Alternative Title:
  IARC Technical Publication No. 42 [TR-42]: Identification of research needs to resolve the carcinogenicity of high-priority IARC Carcinogens
• Personal Author:
  Schubauer-Berigan, Mary K.
• Description:
  Exposure assessments for epidemiologic studies often require the use of retrospective techniques to make use of historical measurement data to create a job-exposure matrix. To be most successful, this technique relies on the past collection and retention of comprehensive, relevant exposure data. Such data frequently consists of industrial hygiene measurements of air concentrations (either area-wide or in the workers' breathing zone). As mentioned above, cohort-wide collection and analysis of biological samples for exposure biomarkers can be employed to good effect; however, this can be expensive and impractical to conduct. Either technique requires consideration of whether adequate latency exists between the measured exposure and the cancer outcome (frequently, mortality) to permit useful evaluation of risk from the exposure. This limitation may be minimized by using validated biomarkers of early effect in lieu of cancer as an outcome (e.g., as discussed in this paper for indium). Practical limitations such as the inability of researchers to access populations or historical exposure information may hamper the ability to develop quantitative exposure estimates for epidemiologic studies of these Group 2 agents. Employers and government agencies should be encouraged to conduct and make available comprehensive exposure assessments that could be used for current or future epidemiologic studies. [Description provided by NIOSH]
• Subjects:
  Biomarkers Carcinogens Environmental Monitoring Epidemiology Neoplasms Occupational Health Safety
• Keywords:
  Cancer Carcinogenesis Carcinogenicity Exposure-assessment Exposure-levels Exposure-limits
• ISBN:
  9789283224495
• ISSN:
  1012-7348
• Publisher:
  International Agency for Research on Cancer
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  214-215
• Volume:
  42
• NIOSHTIC Number:
  nn:20037195
• Citation:
  Identification of research needs to resolve the carcinogenicity of high-priority IARC Carcinogens. Views and expert opinions of an IARC/NORA expert group meeting, Lyon, France, 30 June - 2 July 2009. Lyon, France: International Agency for Research on Cancer, IARC Technical Publication No. 42. 2010 Jul; 42:214-215
• Federal Fiscal Year:
  2010
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d76ba33a4b8d4d979b1f3b01f6bb8643e82b8e767152794f52e5b4cbcb93ab1590f7afe5d2d9a06081a364cb702be703434551e5b5592ecba27aaafdbad64693
• Download URL:
  https://stacks.cdc.gov/view/cdc/188326/cdc_188326_DS1.pdf
• File Type:
  [PDF - 173.13 KB ]