Oxidative Stress in Carcinogenesis [from: Identification of research needs to resolve the carcinogenicity of high-priority IARC Carcinogens]

Details

• Alternative Title:
  IARC Technical Publication No. 42 [TR-42]: Identification of research needs to resolve the carcinogenicity of high-priority IARC Carcinogens
• Personal Author:
  Caldwell J ; Goldstein BD ; Kuempel, Eileen D.
• Description:
  Although several studies in humans have shown associations between biomarkers of oxidative stress and airborne particulate exposures (Han et al., 2005; Risom et al., 2005; Barregard et al., 2007; Valavanidis et al., 2009), evidence is still lacking on the role of oxidative stress in human carcinogenesis (Loft and Møller, 2006). Lack of specificity and need for standardized and validated methods indicate that careful evaluation is needed in considering the use of oxidative stress biomarkers in epidemiological studies. As for any other biomarkers, research is needed to examine the relationship between exposure to toxic agents and oxidative stress biomarkers, and between these biomarkers and risk of cancer, while controlling for the many individual factors that contribute to oxidative stress. Guidelines on standardizing the collection and measurement of oxidative stress biomarkers in humans (Horvath et al., 2005; ATS, 1999) will facilitate their effective use in epidemiological studies of human cancers. [Description provided by NIOSH]
• Subjects:
  Biomarkers Carcinogens Chemistry Environmental Exposure Environmental Monitoring Environmental Pollution Epidemiology Fatigue Hypersensitivity Neoplasms Occupational Health Oxidants Safety Stress, Psychological

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• Keywords:
  Cancer Carcinogenesis Carcinogenicity Chemical-analysis Chemical-hypersensitivity Environmental-exposure Environmental-hazards Environmental-stress Exposure-assessment Exposure-levels Exposure-limits Humans Oxidation Oxidative-enzymes Oxidative-metabolism Stress

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• ISBN:
  9789283224495
• ISSN:
  1012-7348
• Publisher:
  International Agency for Research on Cancer
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  213-214
• Volume:
  42
• NIOSHTIC Number:
  nn:20037186
• Citation:
  Identification of research needs to resolve the carcinogenicity of high-priority IARC Carcinogens. Views and expert opinions of an IARC/NORA expert group meeting, Lyon, France, 30 June - 2 July 2009. Lyon, France: International Agency for Research on Cancer, IARC Technical Publication No. 42. 2010 Jul; 42:213-214
• CAS Registry Number:
  Nitric oxide (CAS RN 10102-43-9)
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Manufacturing ; Mining
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:11387d5b04376d92d241b0f8187e20c3e60ede8b4be80525a78aa7e7a056afa36551fa2a959a092907079a68ce84b85b8346ad8780d61b635e7bb9a8de04f806
• Download URL:
  https://stacks.cdc.gov/view/cdc/188318/cdc_188318_DS1.pdf
• File Type:
  [PDF - 210.96 KB ]