Design Considerations in Molecular Epidemiology

Details

• Personal Author:
  Rothman N ; Schottenfield D ; Schulte, Paul A.
• Description:
  Molecular epidemiology does not differ in purpose from epidemiology in general, thaI is, the study of the distribution and determinants of healthrelated states and events in populations, and the application of this study to the control of health problems (Last, 1988). Further, molecular epidemiologic studies generally are based on dassic epidemiologic designs. What makes molecular epidemiology distinctive, as discussed in Chapter 1, is its abiliry to look inside the "black box" of the exposure-disease continuum. In the process, it may reduce misclassification of exposure, provide insight into underlying mechanisms, identify gene-gene and gene-environment interactions, and provide information when intervention is potentially more effective. This chapter considers how biomarkers can be used in the major epidemiologic study designs. We first review the biomarker categories that represent the continuum from exposure to disease. We then explore the initial methodologic work necessary to characterize a newly developed biomarker before it is applied in etiologic and intervention studies. Hulka (1991) has defined these as transitional studies that bridge the gap from the laboratory to population-based srudies of disease. We then consider the applicadon of biomarkers to case control, prospective, and screening and intervention studies. Finally, we present examples of various biological markers in epidemiologic study designs. [Description provided by NIOSH]
• Subjects:
  Biomarkers Communicable Disease Control Environmental Monitoring Epidemiology Occupational Health Safety
• Keywords:
  Disease-control Disease-prevention Etiology Exposure-assessment Molecular-biology Molecular-epidemiology
• ISBN:
  9780126323450
• Publisher:
  Academic Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  159-198
• NIOSHTIC Number:
  nn:20037094
• Citation:
  Molecular epidemiology: principles and practices. Schulte PA, Perera FP, eds. San Diego, CA: Academic Press, 1993 Apr; :159-198
• Editor(s):
  Schulte PA; Perera FP
• Federal Fiscal Year:
  1993
• Peer Reviewed:
  False
• Source Full Name:
  Molecular epidemiology: principles and practices
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b1a2ed3a197b5d959f3435e8d93b670abc060124c4daeb4faef2f7784045046ef1187a2bed5ae11562b7ef5e7e34411fd656ba666f8162d7692df4e60b34f3e6
• Download URL:
  https://stacks.cdc.gov/view/cdc/188250/cdc_188250_DS1.pdf
• File Type:
  [PDF - 3.79 MB ]