Calcium-Mediated Silica Cytotoxicity

Details

• Personal Author:
  Banks DE ; Castranova, Vincent ; Ma JKH ; Rojanasakul Y
• Description:
  There is evidence that cytotoxic injury that occurs following phagocytic activation of alveolar macrophages (AMs) by silica particles may be caused by the alteration of intracellular calcium [Ca2+}, homeostasis, as well as the generation of reactive oxygen radicals (ORs). Until recently, however, the relationship between these two mechanisms of injury has not been directly addressed. In the case of reactive oxygen species, there is almost universal agreement that oxygen radicals can cause lipid peroxidation of unsaturated fatty acids within membranes leading to disruption of membrane functions and destruction of cells. As for calcium, the perturbation of its cellular control mechanisms, which leads to sustained accumulation of [Ca2+] has long been recognized as the major determinative factor leading to irreversible cell injury. Several recent studies have indicated that silica can induce a rise in [Ca2+] as well as the generation of ORs, and that the inhibition of these cellular processes by calcium chelators or OR scavengers can prevent cell death. The perturbation of [Ca2+], homeostasis by silica has been shown to activate several degradative enzymes such as phospholipases, proteases, and endonucleases and cause disruptions of cytoskeletal and other structural proteins. The present report will review existing evidence for the involvement of calcium in these cellular processes and its relationship to ORs in silica toxicity. Attempts will also be made to elucidate potential mechanisms involved in these cytotoxic processes. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Antioxidants Free Radicals Lung Diseases Occupational Exposure Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Antioxidation Free-radical-generation Free-radicals Humans Lung-disorders Occupational-hazards Pulmonary-system-disorders Silicates
• ISBN:
  9780849347092
• Publisher:
  CRC Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  151-161
• NIOSHTIC Number:
  nn:20037001
• Citation:
  Silica and silica-induced lung diseases. Castranova V, Vallyathan V, Wallace WE, eds. Boca Raton, FL: CRC Press, 1995 Dec; :151-161
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Editor(s):
  Castranova V; Vallyathan V; Wallace WE
• Federal Fiscal Year:
  1996
• Peer Reviewed:
  False
• Source Full Name:
  Silica and silica-induced lung diseases
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5d38b2a969dac8cfcfb6f790194309a0d7cdaaede3adf58ad0c3e07bac7bde4c02b86fece1c31d35466b9c132f8055f60d742128d2313360875c25ee5db226a8
• Download URL:
  https://stacks.cdc.gov/view/cdc/188182/cdc_188182_DS1.pdf
• File Type:
  [PDF - 3.46 MB ]