Invasive Pneumococcal Disease and 7-Valent Pneumococcal Conjugate Vaccine, the Netherlands

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  van Deursen, Anna M.M. ; van Mens, Suzan P. ; Sanders, Elisabeth A.M. ; Vlaminckx, Bart J.M. ; de Melker, Hester E. ; Schouls, Leo M. ; de Greeff, Sabine C. ; van der Ende, Arie
• Corporate Authors:
  on behalf of the Invasive Pneumococcal Disease Sentinel Surveillance Laboratory Group
• Description:
  In the Netherlands, the national immunization program includes 7-valent pneumococcal conjugate vaccine (PCV7) for all newborns born after April 1, 2006. We compared the incidence of invasive pneumococcal disease (IPD) and patient and disease characteristics before PCV7 introduction (June 2004-June 2006) with those after PCV7 introduction (June 2008-June 2010). Culture-confirmed IPD cases were identified by 9 sentinel laboratories covering ≈25% of the Dutch population. Significant declines in overall IPD incidence were observed in children <2 (60%) and in persons >65 (13%) years of age. A trend toward gradual increases in non-PCV7 serotype IPD infections was observed in all age groups; the largest increases were among persons 50-64 (37%) and >65 (25%) years of age. In adults, the proportion of immunocompromised persons increased among IPD patients. Overall, deaths from IPD decreased from 16% to 12% because of a lower case-fatality rate for persons with non-PCV7 serotype IPD.
• Subjects:
  7-valent Pneumococcal Conjugate Vaccine Adolescent Adult Age-specific Rates Aged Aged, 80 And Over Bacteria Child Child, Preschool CME Epidemiology Herd Immunity Humans Immunization Programs Incidence Infant Invasive Pneumococcal Disease Middle Aged Netherlands PCV7 Pneumococcal Infections Pneumococcal Vaccines Population Surveillance Research Retrospective Studies Serotyping Streptococcus Pneumoniae Surveillance The Netherlands Vaccines Vaccines, Conjugate Young Adult

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• Source:
  Emerg Infect Dis. 18(11):1729-1737.
• Document Type:
  Journal Article
• Volume:
  18
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:69b6c5843104500d58ce53e863958a2dc827200ea6f2589bbb0dd8929c7ba5f3
• Download URL:
  https://stacks.cdc.gov/view/cdc/18790/cdc_18790_DS1.pdf
• File Type:
  [PDF - 228.78 KB ]