Development of a Sampler for Total Aerosol Deposition in the Human Respiratory Tract

Details

• Personal Author:
  Clark P ; Koehler KA ; Volckens J
• Description:
  Studies that seek to associate reduced human health with exposure to occupational and environmental aerosols are often hampered by limitations in the exposure assessment process. One limitation involves the measured exposure metric itself. Current methods for personal exposure assessment are designed to estimate the aspiration of aerosol into the human body. Since a large proportion of inhaled aerosol is subsequently exhaled, a portion of the aspirated aerosol will not contribute to the dose. This leads to variable exposure misclassification (for heterogenous exposures) and increased uncertainty in health effect associations. Alternatively, a metric for respiratory deposition would provide a more physiologically relevant estimate of risk. To address this challenge, we have developed a method to estimate the deposition of aerosol in the human respiratory tract using a sampler engineered from polyurethane foam. Using a semi-empirical model based on inertial, gravitational, and diffusional particle deposition, a foam was engineered to mimic aerosol total deposition in the human respiratory tract. The sampler is comprised of commercially available foam with fiber diameter = 49.5 microm (equivalent to industry standard 100 PPI foam) of 8 cm thickness operating at a face velocity of 1.3 m s(-1). Additionally, the foam sampler yields a relatively low-pressure drop, independent of aerosol loading, providing uniform particle collection efficiency over time. [Description provided by NIOSH]
• Subjects:
  Aerosols Environmental Monitoring Irritants Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Aerosols Exposure-assessment Exposure-levels Exposure-methods Exposure Estimation Gravimetric Analysis Inhalation-studies Particle-aerodynamics Particle-counters Respiratory-irritants Respiratory-system-disorders Samplers Sampling

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• ISSN:
  0003-4878
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  53
• Issue:
  7
• NIOSHTIC Number:
  nn:20036436
• Citation:
  Ann Occup Hyg 2009 Oct; 53(7):731-738
• Contact Point Address:
  John Volckens, Department of Environmental and Radiological Health Sciences, Colorado State University, 1681 Campus Delivery, Fort Collins, CO 80523
• Email:
  john.volckens@colostate.edu
• Federal Fiscal Year:
  2010
• Performing Organization:
  Colorado State University - Fort Collins
• Peer Reviewed:
  True
• Start Date:
  20070801
• Source Full Name:
  Annals of Occupational Hygiene
• End Date:
  20090731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bf75d989781a34beee8ca86a0e69c79a152f8a3b11c91bd3ed3fe56bbc8c1da629448ae5ac5853161e78cbf3b01d19552851675e062dfde4871d92d9cffbe4eb
• Download URL:
  https://stacks.cdc.gov/view/cdc/187867/cdc_187867_DS1.pdf
• File Type:
  [PDF - 206.67 KB ]