Development of a sampler to estimate regional deposition of aerosol in the human respiratory tract

Details

• Personal Author:
  Koehler KA ; Volckens J
• Description:
  A multistage sampler was developed and tested to estimate regional deposition of aerosol in the human respiratory system. The motivation for this research is to improve our ability to estimate inhaled aerosol dose. Current methods for aerosol measurement and exposure/risk assessment are based on particle aspiration (e.g. inhalable PM) or on penetration to various regions of the respiratory system (e.g. PM10). The sampler developed here operates at 1 m3 h-1 (16.7 l min-1) of flow and utilizes several substrates, connected in series, to mimic regional particle deposition. Two sets of polyurethane foam substrates are used to mimic particle deposition in the head airways and tracheobronchial regions, respectively. Particle deposition in the alveolar region is mimicked using diffusion screens. These substrates are amenable to trace chemical analyses but not gravimetric analyses, due to water vapor uptake with small changes in relative humidity. [Description provided by NIOSH]
• Subjects:
  Aerosols Chemistry Endotoxins Environmental Monitoring Irritants Laboratories Lung Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Airway-obstruction Airway-resistance Alveolar-cells Author Keywords: Aerosols Chemical-analysis Endotoxin Exposure-assessment Exposure-levels Exposure-methods Exposure Assessment Inhalation-studies Laboratory-testing Measurement-equipment Particle-aerodynamics Particle-counters Respiratory-irritants Respiratory-system-disorders Samplers Sampling

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• ISSN:
  0003-4878
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Maryland ; OSHA Region 3 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  57
• Issue:
  9
• NIOSHTIC Number:
  nn:20043249
• Citation:
  Ann Occup Hyg 2013 Sep; 57(9):1138-1147
• Contact Point Address:
  Kirsten A.Koehler, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
• Email:
  kirsten.koehler@colostate.edu
• Federal Fiscal Year:
  2013
• Performing Organization:
  Colorado State University - Fort Collins
• Peer Reviewed:
  True
• Start Date:
  20070801
• Source Full Name:
  Annals of Occupational Hygiene
• End Date:
  20090731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d1c4d4530311b34e638b980dcf075e12e525c154250fbcdc8f270661b2b0d28dc65475c064f3f1a50f7c421296fb471657e9aee15522282b5a34c1087ba7775f
• Download URL:
  https://stacks.cdc.gov/view/cdc/195190/cdc_195190_DS1.pdf
• File Type:
  [PDF - 970.18 KB ]