Excessive Longitudinal FEV1 Decline and Risks to Future Health: A Case-Control Study

Details

• Personal Author:
  Avashia BH ; Petsonk, Edward L. ; Wang, Mei Lin ; Wood J ; Avashia BH ; Petsonk, Edward L. ; Wang, Mei Lin ; Wood J
• Description:
  Background: Accelerated loss of forced expiratory volume in 1 s (FEV1) in an individual is considered an indicator of developing lung disease. Methods: We investigated longitudinal FEV1 slopes, calculated by simple linear regression, and adverse health outcomes after 10-30 years, among 1,428 chemical plant workers. Cases were defined by FEV1 slopes below 5th percentile values for the cohort. Cases were matched with controls (107 pairs) for race, gender, smoking status, year of birth, age, height, and calendar year at first test. Matched pair statistics were used for comparisons. Results: Cases had a higher proportion, compared to controls, of diagnosis of COPD or emphysema (17.8% vs. 1.9%, P¼0.0002), medication use for respiratory diseases (24.3% vs. 4.7%, P<0.0001), dyspnea (15% vs. 3.7%, P¼0.0042), and wheezing or rhonchi on examination (10.3% vs. 1.9%, P¼0.0225). Conclusions: Chemical plant workers who experienced accelerated FEV1 declines experienced four to nine times as many adverse health conditions over 10-30 years. [Description provided by NIOSH]
• Subjects:
  Case Reports Demography Environmental Monitoring Hazardous Substances Irritants Lung Lung Diseases Manufacturing And Industrial Facilities Occupational Exposure Occupational Health Respiratory Function Tests Respiratory System Respiratory Tract Diseases Safety Workplace

  More +
• Keywords:
  Author Keywords: Spirometry Case-studies Chemical-factory-workers Chemical-industry-workers Chemical-manufacturing-industry Chronic Obstructive Demographic-characteristics Excessive FEV1 Decline Exposure-assessment Exposure-levels Exposure-methods Health-hazards Humans Inhalation-studies Lung-function Mass Screening Occupational-exposure Occupational-hazards Occupational-health Occupational-respiratory-disease Pulmonary-disorders Pulmonary-function Pulmonary-function-tests Pulmonary-system-disorders Pulmonary Disease Respiratory-function-tests Respiratory-irritants Respiratory-system-disorders Statistical-analysis Surveillance Work-environment Worker-health Workplace-studies

  More +
• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  52
• Issue:
  12
• NIOSHTIC Number:
  nn:20036042
• Citation:
  Am J Ind Med 2009 Dec; 52(12):909-915
• Contact Point Address:
  Edward L. Petsonk, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mail Stop H-G900-2,1095 Willowdale Road, Morgantown, WV 26505
• Email:
  elp2@cdc.gov
• Federal Fiscal Year:
  2010
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e8f256598d6eafa76fc65483aacdd4d9754a1bce6632c56e9758d2f667ec190429540434d2bfea807d9bbd033cc40168a572f52543b843bacf77430a1ca90851
• Download URL:
  https://stacks.cdc.gov/view/cdc/187650/cdc_187650_DS1.pdf
• File Type:
  [PDF - 164.97 KB ]