Persistent Reduction of Conduction Velocity and Myelinated Axon Damage in Vibrated Rat Tail Nerves

Details

• Personal Author:
  Kao D ; Loffredo MA ; Matloub, Hani S. ; Riley, Danny A. ; Yan JG ; Zhang LL
• Description:
  Prolonged hand-transmitted vibration exposure in the workplace has been recognized for almost a century to cause neurodegenerative and vasospastic disease. Persistence of the diseased state for years after cessation of tool use is of grave concern. To understand persistence of vibration injury, the present study examined recovery of nerve conduction velocity and structural damage of myelinated axons in a rat tail vibration model. Both 7 and 14 days of vibration (4 h/day) decreased conduction velocity. The decrease correlated directly with the increased percentage of disrupted myelinated axons. The total number of myelinated axons was unchanged. During 2 months of recovery, conduction velocity returned to control level after 7-day vibration but remained decreased after 14-day vibration. The rat tail model provides insight into understanding the persistence of neural deficits in hand-arm vibration syndrome. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Monitoring Laboratories Musculoskeletal System Nervous System Occupational Exposure Occupational Health Safety Sense Organs Vibration
• Keywords:
  Animal-studies Author Keywords: Hand-arm Vibration Syndrome Demyelination Exposure-assessment Exposure-levels Exposure-methods Hand-injuries Hand-tools Injuries Laboratory-animals Laboratory-testing Muscle-tissue Muscles Nerve-damage Nerve-fiber-excitation Nerve-fibers Nerve-function Nerve-tissue Nerve Edema Nerves Neurological-reactions Neuropathy Occupational-exposure Occupational-hazards Occupational Raynaud Disease Peripheral Nerve Power-tools Sensory-disorders Vibration-disease Vibration-effects Vibration-exposure

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• ISSN:
  0148-639X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  39
• Issue:
  6
• NIOSHTIC Number:
  nn:20035756
• Citation:
  Muscle Nerve 2009 Jun; 39(6):770-775
• Contact Point Address:
  Danny A. Riley, Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226
• Email:
  dariley@mcw.edu
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Manufacturing ; Wholesale and Retail Trade
• Performing Organization:
  Medical College of Wisconsin, Milwaukee, Wisconsin
• Peer Reviewed:
  True
• Start Date:
  19990901
• Source Full Name:
  Muscle & Nerve
• End Date:
  20160831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d242a1779a2757b15ad28abb1ad0e2f2866557f13bdde4d1942728f45d726951a7e293f745af65694c43a9da486fcd3c224c3a7b17e101824dca8b2ecd648cb3
• Download URL:
  https://stacks.cdc.gov/view/cdc/187498/cdc_187498_DS1.pdf
• File Type:
  [PDF - 173.21 KB ]