Frequency-dependent effects of vibration on peripheral nerves and sensory nerve function in a rat model of hand-arm vibration syndrome

Details

• Personal Author:
  Johnson C ; Kashon ML ; Krajnak, Kristine M. ; Miller, G. Roger ; Waugh, Stacey
• Description:
  Objective: Occupational exposure to hand-transmitted vibration can result in damage to nerves and sensory loss. The goal of this study was to assess the frequency-dependent effects of repeated bouts of vibration on sensory nerve function and associated changes in nerves. Methods: The tails of rats were exposed to vibration at 62.5, 125, or 250 Hz (constant acceleration of 49 m/s(2)) for 10 days. The effects on sensory nerve function, nerve morphology, and transcript expression in ventral tail nerves were measured. Results: Vibration at all frequencies had effects on nerve function and physiology. However, the effects tended to be more prominent with exposure at 250 Hz. Conclusion: Exposure to vibration has detrimental effects on sensory nerve function and physiology. However, many of these changes are more prominent at 250-Hz exposure than at lower frequencies. (Erratum: Characterization of frequency-dependent responses of the vascular system.... [Description provided by NIOSH]
• Subjects:
  Animals Environmental Monitoring Laboratories Musculoskeletal System Nervous System Occupational Health Safety Sense Organs Vibration
• Keywords:
  Animal-studies Exposure-assessment Exposure-levels Hand-injuries Hand-tools Injury-prevention Laboratory-animals Nerve-damage Nerve-function Neurological-reactions Neurophysiological-effects Physiological-effects Repetitive-work Sensory-disorders Vibration-disease Vibration-effects Vibration-exposure

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• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  54
• Issue:
  8
• NIOSHTIC Number:
  nn:20041506
• Citation:
  J Occup Environ Med 2012 Aug; 54(8):1010-1016
• Contact Point Address:
  Kristine Krajnak, PhD, Biostatics and Epidemiology Branch, NIOSH, 1095 Willowdale Road, MS2027, Morgantown, WV 26505
• Email:
  ksk1@cdc.gov
• Federal Fiscal Year:
  2012
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7a867043fa544d6fbff99303e8b1efee96dc8c67e3d053a07dde8fb0c31c30acdfffc51e4c3276ae0d2b47368a298fcfd6cb7baaca007e55f2ead67ced1d96b7
• Download URL:
  https://stacks.cdc.gov/view/cdc/194058/cdc_194058_DS1.pdf
• File Type:
  [PDF - 262.44 KB ]