Comparison of Continuous and Intermittent Vibration Effects on Rat-Tail Artery and Nerve

Details

• Personal Author:
  Bain JL ; Curry BD ; Govindaraju SR ; Riley, Danny A.
• Description:
  Hand-transmitted vibration from powered-tools can cause peripheral vasospasm and neuropathy. A rat-tail model was used to investigate whether the pattern of vibration influenced the type and severity of tissue damage. The tails of awake rats were vibrated continuously or intermittently for a total of 4 hours at 60 HZ, 49 m/s(2). Nerves and arteries were harvested immediately or 24 hours after treatment. Tails subjected to intermittent vibration showed transiently increased sensitivity to thermal stimuli. Intermittent vibration caused the most nerve injury immediately and 24 hours after vibration. Continuous vibration invoked a persistent reduction in vascular lumen size. Compared to epinephrine-induced transient vacuolation in vascular smooth muscle cells, both continuous and intermittent vibration caused greater persistence of vacuoles, indicating a vibration-induced pathological process. All vibration groups exhibited elevated nitrotyrosine immunoreactivity indicative of free-radical damage. Pattern of vibration exposure may exert a major influence on the type of vibration injury. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Monitoring Free Radicals Laboratories Musculoskeletal System Nervous System Occupational Health Safety Vibration
• Keywords:
  Animal-studies Exposure-assessment Exposure-levels Free-radicals Hand-injuries Hand-tools Injuries Laboratory-animals Muscle-tissue Muscles Nerves Neuropathy Vibration-effects Vibration-exposure

  More +
• ISSN:
  0148-639X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  197-204
• Volume:
  34
• Issue:
  2
• NIOSHTIC Number:
  nn:20030888
• Citation:
  Muscle Nerve 2006 Aug; 34(2):197-204
• Contact Point Address:
  Danny A. Riley, Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
• Email:
  dariley@mcw.edu
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  Medical College of Wisconsin, Milwaukee, Wisconsin
• Peer Reviewed:
  True
• Start Date:
  19990901
• Source Full Name:
  Muscle & Nerve
• End Date:
  20160831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bf33ce9f409ed9646e987b5633ec5b486adc139d5b8395786af3e7880de09a9e948e4e4e32794fd47462e3026a5f0cb9fa0771a2b176e6f729126bd55bd2522a
• Download URL:
  https://stacks.cdc.gov/view/cdc/191345/cdc_191345_DS1.pdf
• File Type:
  [PDF - 431.38 KB ]