HIV Infection and Geographically Bound Transmission of Drug-Resistant Tuberculosis, Argentina

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ritacco, Viviana ; López, Beatriz ; Ambroggi, Marta ; Palmero, Domingo ; Salvadores, Bernardo ; Gravina, Elida ; Mazzeo, Eduardo ; Imaz, Susana ; Barrera, Lucía
• Corporate Authors:
  National TB Laboratory Network
• Description:
  During 2003-2009, the National Tuberculosis (TB) Laboratory Network in Argentina gave 830 patients a new diagnosis of multidrug-resistant (MDR) TB and 53 a diagnosis of extensively drug- resistant (XDR) TB. HIV co-infection was involved in nearly one third of these cases. Strain genotyping showed that 7 major clusters gathered 56% of patients within restricted geographic areas. The 3 largest clusters corresponded to epidemic MDR TB strains that have been undergoing transmission for >10 years. The indigenous M strain accounted for 29% and 40% of MDR and XDR TB cases, respectively. Drug-resistant TB trends in Argentina are driven by spread of a few strains in hotspots where the rate of HIV infection is high. To curb transmission, the national TB program is focusing stringent interventions in these areas by strengthening infection control in large hospitals and prisons, expediting drug resistance detection, and streamlining information-sharing systems between HIV and TB programs.
• Subjects:
  Adolescent Adult Aged Antimicrobial Resistance Argentina Child Cluster Analysis Co-infection Coinfection Disease Transmission Extensively Drug Resistant Tuberculosis Female Genotype Geography HIV HIV Infections Humans Male MDR TB Middle Aged Multidrug-resistant Tuberculosis Mycobacterium Tuberculosis Research Restriction Fragment Length Polymorphism TB Tuberculosis, Multidrug-Resistant Tuberculosis And Other Mycobacteria XDR TB Young Adult

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• Source:
  Emerg Infect Dis. 18(11):1802-1810.
• Document Type:
  Journal Article
• Volume:
  18
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:1a66b01a1d2b1fc27a3415dd6092f6d06871f3178d899af2c7d5d57cf9c2dcf1
• Download URL:
  https://stacks.cdc.gov/view/cdc/18741/cdc_18741_DS1.pdf
• File Type:
  [PDF - 321.32 KB ]