Multiple Introductions of Multidrug-Resistant Tuberculosis into Households, Lima, Peru

Cohen, Ted; Murray, Megan; Abubakar, Ibrahim; Zhang, Zibiao; Sloutsky, Alexander; Arteaga, Fernando; Chalco, Katiuska; Franke, Molly F.; Becerra, Mercedes C.

i

Multiple Introductions of Multidrug-Resistant Tuberculosis into Households, Lima, Peru

Supporting Files Public Domain

Jun 2011
By Cohen, Ted ; Murray, Megan ; Abubakar, Ibrahim ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Cohen, Ted ; Murray, Megan ; Abubakar, Ibrahim ; Zhang, Zibiao ; Sloutsky, Alexander ; Arteaga, Fernando ; Chalco, Katiuska ; Franke, Molly F. ; Becerra, Mercedes C.
Description:

Two cases of multidrug-resistant tuberculosis (MDR TB) in a household are assumed to reflect within-household transmission. However, in high-incidence areas of MDR TB, secondary cases may arise through exposure to MDR TB in the community. To estimate the frequency of multiple introductions of MDR TB into households, we used spoligotyping and 24-loci mycobacterial interspersed repetitive unit- variable number tandem repeats to classify isolates from 101 households in Lima, Peru, in which >1 MDR TB patient received treatment during 1996-2004. We found different MDR TB strains in >10% of households. Alternate approaches for classifying matching strains produced estimates of multiple introductions in <38% of households. At least 4% of MDR TB patients were reinfected by a second strain of MDR Mycobacterium tuberculosis. These findings suggest that community exposure to MDR TB in Lima occurs frequently. Rapid drug sensitivity testing of strains from household contacts of known MDR TB patients is needed to identify optimal treatment regimens.
Subjects:

Antimicrobial Resistance Bacteria Family Characteristics Genes, Bacterial Genotype Household Humans MDR TB Multidrug-resistant Tuberculosis Mycobacterium Tuberculosis Peru Research Transmission Tuberculosis, Multidrug-Resistant Tuberculosis And Other Mycobacteria
Source:

Emerg Infect Dis. 17(6):969-975.
Document Type:

Journal Article
Volume:

17
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:e995686c107f2dde316ecd093d4b25b7a39326ec4487f7afee56643653e6d729
Download URL:

https://stacks.cdc.gov/view/cdc/18485/cdc_18485_DS1.pdf
File Type:

[PDF - 189.16 KB ]

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.