Manganese Accumulation in the Mouse Ear Following Systemic Exposure

Details

• Personal Author:
  Afton SE ; Caruso JA ; Genter MB ; Lind C ; Ma C ; Miller M ; Nebert DW ; Roda SM ; Schneider SN
• Description:
  There is evidence in human populations that exposure to manganese (Mn), or Mn in combination with excessive noise exposure, results in hearing loss. Quantitative reverse-transcriptase polymerase chain reaction revealed expression of the metal transporters DMT1, ZIP8, and ZIP14 in control mouse ears. ZIP8 is known to have a high affinity (K(m) = 2.2 microM) for Mn transport, and ZIP8 protein was localized to the blood vessels of the ear by immunohistochemistry. We treated mice (strains C57BL/6J and DBA/2J) with Mn (100 mg/kg MnCl(2), by subcutaneous injection, on three alternating days), and Mn was significantly elevated in the ears of the treated mice. Mn concentrations remained elevated over controls for at least 2 weeks after treatment. These studies demonstrate that metal transporters are present in the mouse ear and that Mn can accumulate in the ear following systemic exposure. Future studies should focus on whether Mn exposure is associated with hearing deficits. [Description provided by NIOSH]
• Subjects:
  Biochemistry Biological Factors Ear Environmental Monitoring Hazardous Substances Hearing Hearing Loss Hearing Loss, Noise-Induced Hypersensitivity Immune System Laboratories Occupational Exposure Occupational Health Safety Safety Management Sense Organs

  More +
• Keywords:
  Author Keywords: Manganese Biochemical-indicators Biohazards Biological-effects Biological-factors Biological-systems Chemical-hypersensitivity Dmt1 Ear-disorders Ears Exposure-assessment Exposure-methods Health-hazards Hearing-acuity Hearing-disorders Hearing-impairment Immune-system Immunochemistry Laboratory-animals Laboratory-testing Microchemistry Molecular-biology Mouse Occupational-exposure Occupational-hazards Safety-measures Slc39a8 Slc39a14 Statistical-analysis ZIP8

  More +
• ISSN:
  1095-6670
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  305-310
• Volume:
  22
• Issue:
  5
• NIOSHTIC Number:
  nn:20035117
• Citation:
  J Biochem Mol Toxicol 2008 Sep; 22(5):305-310
• Contact Point Address:
  Mary Beth Genter, Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056
• Email:
  Marybeth.genter@uc.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2008
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Journal of Biochemical and Molecular Toxicology
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:712f300cef1a988536374ef5b784a3b4575b99a0b34e11e40245dcf50289a131530cacf9b0e427196e5538e016435c8c2f04928ec8bd8858edd8e35357be4ca0
• Download URL:
  https://stacks.cdc.gov/view/cdc/187075/cdc_187075_DS1.pdf
• File Type:
  [PDF - 131.67 KB ]