Effect of Chronic Low Level Manganese Exposure on Postural Balance: A Pilot Study of Residents in Southern Ohio

Details

• Personal Author:
  Bhattacharya, Amit ; Cox, Clinton ; Haynes E ; Standridge JS ; Succop P
• Description:
  OBJECTIVE: The objective of this study was to determine the effect of non-occupational exposure to manganese (Mn) on postural balance. METHODS: Residents living near a ferromanganese refinery provided hair and blood samples after postural balance testing. The relationship between hair Mn and postural balance was analyzed with logistic regression. Following covariate adjustment, postural balance was compared with control data by analysis of covariance. RESULTS: Mean hair Mn was 4.4 microg/g. A significantly positive association was found between hair Mn and sway area (eyes open on the platform, P = 0.05; eyes closed on the platform, P = 0.04) and sway length (eyes open on the platform, P = 0.05; eyes closed on the platform, P = 0.04). Postural balance of residents was significantly larger than controls in 5 out of 8 postural balance outcomes. CONCLUSION: Preliminary findings suggest subclinical impairment in postural balance among residents chronically exposed to ambient Mn. A prospective study with a larger sample size is warranted. [Description provided by NIOSH]
• Subjects:
  Biochemistry Biological Factors Ear Environmental Exposure Environmental Monitoring Environmental Pollution Ergonomics Hazardous Substances Hypersensitivity Musculoskeletal System Occupational Health Safety Safety Management Sense Organs

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• Keywords:
  Author Keywords: Mouse Biochemical-indicators Biohazards Biological-effects Biological-factors Biological-systems Chemical-hypersensitivity Dmt1 Ear-disorders Environmental-contamination Environmental-exposure Environmental-hazards Environmental-pollution Exposure-assessment Exposure-methods Health-hazards Humans Microchemistry Molecular-biology Posture Safety-measures Slc39a8 Slc39a14 Statistical-analysis ZIP8

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  50
• Issue:
  12
• NIOSHTIC Number:
  nn:20035357
• Citation:
  J Occup Environ Med 2008 Dec; 50(12):1421-1429
• Contact Point Address:
  Mary Beth Genter, Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056
• Email:
  Marybeth.genter@uc.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2009
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:268cc04b256d56a6ec07c2f39927e758bd7490e626738caadcc714d8a23239c41ecf16044c674dfac045db9070a580697bffae7c22556bfaa164e8c9d125b92d
• Download URL:
  https://stacks.cdc.gov/view/cdc/187244/cdc_187244_DS1.pdf
• File Type:
  [PDF - 475.38 KB ]