Nanotechnology-Based Electrochemical Sensors for Biomonitoring Chemical Exposures

Details

• Personal Author:
  Barry RC ; Lin Y ; Liu G ; Timchalk CA ; Wang J
• Description:
  The coupling of dosimetry measurements and modeling represents a promising strategy for deciphering the relationship between chemical exposure and disease outcome. To support the development and implementation of biological monitoring programs, quantitative technologies for measuring xenobiotic exposure are needed. The development of portable nanotechnology-based electrochemical (EC) sensors has the potential to meet the needs for low cost, rapid, high-throughput, and ultrasensitive detectors for biomonitoring an array of chemical markers. Highly selective EC sensors capable of pM sensitivity, high-throughput and low sample requirements (<50 microl) are discussed. These portable analytical systems have many advantages over currently available technologies, thus potentially representing the next generation of biomonitoring analyzers. This paper highlights research focused on the development of field-deployable analytical instruments based on EC detection. Background information and a general overview of EC detection methods and integrated use of nanomaterials in the development of these sensors are provided. New developments in EC sensors using various types of screen-printed electrodes, integrated nanomaterials, and immunoassays are presented. Recent applications of EC sensors for assessing exposure to pesticides or detecting biomarkers of disease are highlighted to demonstrate the ability to monitor chemical metabolites, enzyme activity, or protein biomarkers of disease. In addition, future considerations and opportunities for advancing the use of EC platforms for dosimetric studies are discussed. [Description provided by NIOSH]
• Subjects:
  Biochemistry Biological Factors Biomarkers Chemistry Hypersensitivity Occupational Health Particulate Matter Safety
• Keywords:
  Author Keywords: Biomonitoring Biochemical-indicators Biological-effects Biological-factors Biological-monitoring Chemical-agent-detectors Chemical-analysis Chemical-hypersensitivity Chemical-properties Dosimetry Electrochemical-analysis Electrochemical-reactions Electrochemical Sensors Electrochemistry Exposure Assessment Mathematical-models Nanotechnology Particulate-sampling-methods Qualitative-analysis

  More +
• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-18
• Volume:
  19
• Issue:
  1
• NIOSHTIC Number:
  nn:20034974
• Citation:
  J Expo Sci Environ Epidemiol 2009 Jan; 19(1):1-18
• Contact Point Address:
  Dr. Charles A. Timchalk, Biological Monitoring and Modeling Group, Pacific Northwest National Laboratory, MSIN: P7-59, 902 Battelle Blvd., Richland, WA 99352
• Email:
  charles.timchalk@pnl.gov
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  Battelle Pacific Northwest Laboratories
• Peer Reviewed:
  True
• Start Date:
  20060901
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1ad871583214d1d369a445e16403683ea2c4e33b21653920a8212d348537f9b14f3de2c3477d114605d4526b494f5847c2851715e5a060fdff753fdf60155885
• Download URL:
  https://stacks.cdc.gov/view/cdc/186981/cdc_186981_DS1.pdf
• File Type:
  [PDF - 462.12 KB ]