Apoptosis Gene Polymorphisms, Age, Smoking and the Risk of Non-Small Cell Lung Cancer

Details

• Personal Author:
  Asomaning K ; Christiani, David C. ; Devivo I ; Heist RS ; Lin X ; Liu G ; Lynch TJ ; Su L ; Ter-Minassian M ; Wain JC ; Zhai R ; Zhou W
• Description:
  Apoptosis is important for targeting cancer cells for destruction. Various single-nucleotide polymorphisms (SNPs) in apoptotic genes have been associated with increased risks in lung cancer, particularly FAS -1377 G>A (rs2234767), FASLG -844 C>T (rs763110), IL1B +3954 C>T Phe105Phe (rs1143634) and BAT3 Ser625Pro (rs1052486). We studied the association of these SNPs with non-small cell lung cancer (NSCLC) in a large case-control study (N = 4263: 2644 cases and 1619 controls). No associations with NSCLC were observed in the main effects analysis for all four SNPs, adjusting for age, gender, smoking status, pack-years and years since smoking cessation. In subjects under age 60, for FASLG -844 C>T polymorphism, CT compared with the CC genotype, was significantly associated with increased risk of NSCLC, adjusted odds ratio (aOR) = 1.58 (1.22, 2.05), P = 0.0006 and TT aOR = 1.45 (1.01, 2.04), P = 0.04. In contrast, for those over age 60, the CT aOR = 0.91 (0.73, 1.13), P = 0.37 and TT aOR = 0.86 (0.64, 1.16), P = 0.32. The P-value for the age-genotype interaction was 0.004. For the IL1B +3954 C>T polymorphism, compared with the CC genotype, TT showed significant associations in former smokers and in men but tests of interaction were not significant (P(smoking) = 0.24, P(gender) = 0.17). No interactions were observed for FAS -1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG -844 and IL1B + 3954 SNPs with the risk of NSCLC. [Description provided by NIOSH]
• Subjects:
  Age Factors Genetics Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smokers

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• Keywords:
  Age-factors Genes Genetic-disorders Genetic-factors Lung-cells Lung-disease Pulmonary-cancer Pulmonary-disorders Pulmonary-system-disorders Risk-factors Smoking Statistical-analysis

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• ISSN:
  0143-3334
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  29
• Issue:
  11
• NIOSHTIC Number:
  nn:20034811
• Citation:
  Carcinogenesis 2008 Nov; 29(11):2147-2152
• Contact Point Address:
  Monica Ter-Minassian, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115
• Email:
  mtermina@hsph.harvard.edu
• Federal Fiscal Year:
  2009
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Carcinogenesis
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fb4a33f6340da023039d49ec86aa9b608eb01013fe8db0e1126cbbf9a7f3fd3a86adc8a1f32bd83993ea672c4243e7473270e3c000636f2355b3091977a11716
• Download URL:
  https://stacks.cdc.gov/view/cdc/186875/cdc_186875_DS1.pdf
• File Type:
  [PDF - 102.26 KB ]