Lung Cancer Risk in Families of Nonsmoking Probands: Heterogeneity by Age at Diagnosis

Details

• Personal Author:
  Aston CE ; McAllister AE ; Schwartz AG ; Swanson GM ; Yang P
• Description:
  In an earlier investigation, we did not detect a major genetic component to lung cancer in families of nonsmoking lung cancer probands. However, heterogeneity with respect to familial aggregation, based on probands' age at diagnosis, was evident. We reanalyzed our previously collected data of 257 families, stratified by age at diagnosis of the probands, using complex segregation analysis. We specifically tested the effects of a Mendelian diallelic gene, history of tobacco use, and history of selected chronic lung diseases in families with a proband diagnosed at the age of 60 years or older and in families with a younger proband (i.e. , under 60 years of age). Cases were identified from the Metropolitan Detroit Cancer Surveillance System. Information on lung cancer occurrence, smoking history, and chronic respiratory diseases in first-degree relatives was obtained for 210 older probands and for 47 younger probands. In older probands' families, no evidence of a major genetic effect was detected. A history of emphysema and tobacco-smoke exposure were found to be significant risk factors. In younger probands' families, a Mendelian codominant model with significant modifying effects of smoking and chronic bronchitis best explained the observed data. Our results suggest the presence of a high-risk gene contributing to early-onset lung cancer in a population where the probands are nonsmokers. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Demography Epidemiology Family Genetics Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smoke Smokers Tobacco Products

  More +
• Keywords:
  Age-factors Age-groups Cancer Cigarette-smoking Demographic-characteristics Families Genetic-factors Lung-cancer Models Respiratory-system-disorders Risk-analysis Risk-factors Smoking Tobacco Tobacco-smoke

  More +
• ISSN:
  0741-0395
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; Minnesota ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  253-273
• Volume:
  17
• Issue:
  4
• NIOSHTIC Number:
  nn:20031378
• Citation:
  Genet Epidemiol 1999 Nov; 17(4):253-273
• Contact Point Address:
  P. Yang, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905
• Email:
  yang.ping@mayo.edu
• Federal Fiscal Year:
  1998
• Performing Organization:
  Michigan Cancer Foundation, Detroit, Michigan
• Peer Reviewed:
  True
• Start Date:
  19840928
• Source Full Name:
  Genetic Epidemiology
• End Date:
  19940929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a1215aca1ff5614306f3ccecbd1f4c7aa90fcb7d0c9ae4dfc05e6adda351c09d20e3e1cba0e2b152309511ca241e04305bd80d6cc096be08ea7defd5c87e56d8
• Download URL:
  https://stacks.cdc.gov/view/cdc/191638/cdc_191638_DS1.pdf
• File Type:
  [PDF - 193.38 KB ]