Interindividual Differences in the Concentration of 1-Hydroxypyrene-Glucuronide in Urine and Polycyclic Aromatic Hydrocarbon-DNA Adducts in Peripheral White Blood-Cells After Charbroiled Beef Consumption

Details

• Personal Author:
  Baser ME ; Greenberg A ; Groopman JD ; Hsu CH ; Kang DH ; Poirier MC ; Rothman N ; Schwartz BS ; Strickland PT ; Weston A
• Description:
  Apoptosis is important for targeting cancer cells for destruction. Various single-nucleotide polymorphisms (SNPs) in apoptotic genes have been associated with increased risks in lung cancer, particularly FAS -1377 G>A (rs2234767), FASLG -844 C>T (rs763110), IL1B +3954 C>T Phe105Phe (rs1143634) and BAT3 Ser625Pro (rs1052486). We studied the association of these SNPs with non-small cell lung cancer (NSCLC) in a large case-control study (N = 4263: 2644 cases and 1619 controls). No associations with NSCLC were observed in the main effects analysis for all four SNPs, adjusting for age, gender, smoking status, pack-years and years since smoking cessation. In subjects under age 60, for FASLG -844 C>T polymorphism, CT compared with the CC genotype, was significantly associated with increased risk of NSCLC, adjusted odds ratio (aOR) = 1.58 (1.22, 2.05), P = 0.0006 and TT aOR = 1.45 (1.01, 2.04), P = 0.04. In contrast, for those over age 60, the CT aOR = 0.91 (0.73, 1.13), P = 0.37 and TT aOR = 0.86 (0.64, 1.16), P = 0.32. The P-value for the age-genotype interaction was 0.004. For the IL1B +3954 C>T polymorphism, compared with the CC genotype, TT showed significant associations in former smokers and in men but tests of interaction were not significant (P(smoking) = 0.24, P(gender) = 0.17). No interactions were observed for FAS -1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG -844 and IL1B + 3954 SNPs with the risk of NSCLC. [Description provided by NIOSH]
• Subjects:
  Age Factors Genetics Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smokers

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• Keywords:
  Age-factors Cancer-rates Cell-alteration Cell-biology Cell-morphology Cell-transformation Cellular-reactions Cellular-transport-mechanism Genes Genetic-disorders Genetic-factors Lung-cells Lung-disease Pulmonary-cancer Pulmonary-disorders Pulmonary-system-disorders Risk-factors Smoking Statistical-analysis

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• ISSN:
  0143-3334
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  5
• NIOSHTIC Number:
  nn:20035627
• Citation:
  Carcinogenesis 1995 May; 16(5):1079-1085
• Contact Point Address:
  DH Kang, CDC, NIOSH, DSHEFS, Hazard Evaluation & Technical Assistance Branch, Cincinnati, OH 45226
• Federal Fiscal Year:
  1995
• Peer Reviewed:
  True
• Source Full Name:
  Carcinogenesis
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ad7bfd95e7220a2a822d13edb11bb9e6d8ac9e17ff038aba8ae772fbfa0bfeebafb8c411f54e9df940b8c4a2d50fb14954ac26f24b60db8c46c52fcb91e3b721
• Download URL:
  https://stacks.cdc.gov/view/cdc/187424/cdc_187424_DS1.pdf
• File Type:
  [PDF - 628.42 KB ]