Cancer Incidence Among Pesticide Applicators Exposed to Captan in the Agricultural Health Study

Details

• Personal Author:
  Alavanja MCR ; Dosemeci, Mustafa ; Greenburg DL ; Hines CJ ; Hoppin JA ; Koutros S ; Patel R ; Rusiecki J
• Description:
  Objective: Captan is a widely used antifungal pesticide whose potential to cause cancer in humans is uncertain. Methods: we evaluated the incidence of cancer among pesticide applicators exposed to captan in the Agricultural Health Study. Detailed information on pesticide exposure and lifestyle factors was obtained from self-administered enrollment questionnaires completed between 1993 and 1997. Results: of the 48,986 applicators enrolled 4,383 (9%) had applied captan. Median follow-up time was 9.14 years. Poisson regression analysis was used to estimate relative risks (RR) for cancer subtypes by tertiles of captan exposure. We investigated risk for all cancers combined and sites of cancer for which at least 15 cases occurred among captan-exposed applicators. These sites included cancers of the prostate, lung, and colon, blood-related cancers, and colorectal cancers. During follow-up 2,912 incident primary cases of cancer were identified. No association between the highest tertile of captan exposure (>67.375 intensity-weighted days) and development of all cancers (RR = 0.89; 95% CI, 0.71-1.13) or cancer of any specific site was observed. Conclusion: although our study is limited by low numbers of observed cancer cases and follow-up time of 9.14 years, it does not provide evidence of an increased risk for the development of cancer at the investigated sites. [Description provided by NIOSH]
• Subjects:
  Agriculture Chemistry Hypersensitivity Insecticides Neoplasms Occupational Health Risk Assessment Safety Surveys And Questionnaires
• Keywords:
  Agricultural-chemicals Agricultural-workers Agricultural Health Study Author Keywords: Captan Cancer Cancer-rates Chemical-hypersensitivity Chemical-properties Cohort Fungicide Pesticide Pesticides Pesticides-and-agricultural-chemicals Prospective Quantitative-analysis Questionnaires Risk-analysis Statistical-analysis

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• ISSN:
  0957-5243
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  10
• NIOSHTIC Number:
  nn:20034709
• Citation:
  Cancer Causes Control 2008 Dec; 19(10):1401-1407
• Contact Point Address:
  Jennifer Rusiecki, Department of Medicine-EDP, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814
• Email:
  jrusiecki@usuhs.mil
• CAS Registry Number:
  Captan (CAS RN 133-06-2)
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Peer Reviewed:
  True
• Source Full Name:
  Cancer Causes and Control
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5322c275936ffa86c54811c0b11199a92bc409779bbf12aa13ab12b179dd50f44817ca8572755a3f256e450bef23088a100f9a09aec8c2f5635d6ac87b2d416a
• Download URL:
  https://stacks.cdc.gov/view/cdc/186816/cdc_186816_DS1.pdf
• File Type:
  [PDF - 169.55 KB ]