Mother’s Menopausal Age Is Associated with Her Daughter’s Early Follicular Phase Urinary Follicle-Stimulating Hormone Level

Details

• Personal Author:
  Baird DD ; Kesner JS ; Steiner AZ
• Description:
  Objective: Early follicular phase follicle-stimulating hormone (FSH), a marker of ovarian reserve, has been used to predict time to menopause. A mother's age at menopause is related to her daughter's age at menopause, possibly because of genetic factors. In this study we sought to determine the relationship between maternal age at menopause and early follicular phase FSH of premenopausal daughters. Design: The Uterine Fibroid Study enrolled women randomly selected from a prepaid health plan, collected questionnaire data, and obtained earl), follicular phase urine samples for a Subset of participants. For this secondary analysis, premenopausal women between the ages of 35 and 46 years, who provided a urine sample on cycle day 2, 3, 4, or 5 and their mother's age at natural menopause (n = 182) were selected from the original cohort. Initially bivariate analysis and subsequently regression modeling were performed to assess the independent relationship between maternal age at menopause and urinary creatinine-corrected FSH. Results: Unadjusted analyses and those adjusting for age (mean +/- SD, 405 +/- 3.2 y), smoking status (16% current smokers), and body mass index (26.8 +/- 6.9 kg/m(2)) showed a significant association between maternal age at menopause and daughter's urinary FSH level (P < 0.04). Women whose mothers experienced earlier menopause had higher urinary FSH levels. Conclusions: The significantly increased FSH values among women whose mothers experienced early menopause is consistent with previously reported associations between mother's and daughter's age of menopause. FSH, a marker of ovarian reserve, is influenced by both genetic and environmental factors. Future epidemiologic studies on FSH should include collection of information on maternal age at menopause. [Description provided by NIOSH]
• Subjects:
  Age Factors Environmental Exposure Environmental Health Epidemiology Genetics Occupational Health Safety Urogenital System
• Keywords:
  Age-factors Environmental-exposure Environmental-factors Genetic-factors Statistical-analysis Urogenital-system
• ISSN:
  1072-3714
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  15
• Issue:
  5
• NIOSHTIC Number:
  nn:20034626
• Citation:
  Menopause 2008 Sep; 15(5):940-944
• Contact Point Address:
  Anne Z. Steiner, MD, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC 27515
• Email:
  asteiner@med.unc.edu
• Federal Fiscal Year:
  2008
• Peer Reviewed:
  True
• Source Full Name:
  Menopause: Journal of the North American Menopause Society
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f7e57ad5f811f6fafd6d964b4caad789590cfc41df9a272895fb7a2f88ffec4514bc39e11534b96cf5172b747a0aa06eca6afaa1b6bf9346812b3e75cdf67033
• Download URL:
  https://stacks.cdc.gov/view/cdc/186765/cdc_186765_DS1.pdf
• File Type:
  [PDF - 1.98 MB ]