Paraoxonase 1 (PON1) Status and Risk of Insecticide Exposure

Details

• Personal Author:
  Cole TB ; Costa LG ; Furlong CR ; Lusis AJ ; Richter RJ ; Shih DM ; Timchalk C ; Tward A ; Walter BJ
• Description:
  Paraoxonase 1 (PON1) is an HDL associated enzyme that catalyzes a number of different reactions including the hydrolysis of the toxic oxon metabolites of the insecticides diazinon and chlorpyrifos. PON1 has also been implicated in the detoxication of oxidized lipids and the metabolism of a number of drugs, activating some, while inactivating others. There are two common PON1 coding region polymorphisms (L55M and Q192R). The latter determines the catalytic efficiency of hydrolysis of a number of substrates including chlorpyrifos oxon, but not diazoxon. Evidence for the physiological importance ofPON1 in modulating exposures to these two insecticides comes from several different studies. Early studies noted that species with high levels of PON1 were much more resistant to certain organophosphorus (OP) insecticides than were species with low levels. Another early study by Main demonstrated that injected rabbit paraoxonase protected rats from paraoxon toxicity. Our research group began the development of a mouse model system for examining the importance of PON1 in the detoxication of OP insecticides. [Description provided by NIOSH]
• Subjects:
  Animals Cardiovascular Diseases Cardiovascular System Environmental Health Insecticides Laboratories Nervous System Nervous System Diseases Occupational Health Organophosphates Safety

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• Keywords:
  Brain-electrical-activity Brain-function Cerebrovascular-system-disorders Environmental-factors In-vitro-studies Insecticide-poisoning Laboratory-animals Models Organo-phosphorus-compounds Organo-phosphorus-pesticides Pesticides Quantitative-analysis

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• ISSN:
  1095-6670
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 10 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  182-183
• Volume:
  19
• Issue:
  3
• NIOSHTIC Number:
  nn:20032920
• Citation:
  J Biochem Mol Toxicol 2005 Apr; 19(3):182-183
• Contact Point Address:
  Clement E. Furlong, Department of Medicine, Division of Medical Genetics, University of Washington, Seattle,WA 98195-7720
• Email:
  clem@u.washington.edu
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Performing Organization:
  Battelle Memorial Institute, Richland, Washington
• Peer Reviewed:
  False
• Start Date:
  20010930
• Source Full Name:
  Journal of Biochemical and Molecular Toxicology
• End Date:
  20050929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7eb8bad335c8fe0f187d8e5f129a21fbde4f25e3f0620f85ab1281ae009af72d923f200ffb9494073cde2b8bd700622e6d32a14fda82cccdc7f4edb1db7451f4
• Download URL:
  https://stacks.cdc.gov/view/cdc/186706/cdc_186706_DS1.pdf
• File Type:
  [PDF - 40.21 KB ]