B Cells Behaving Badly

Details

• Personal Author:
  Caporaso NE ; Linet MS ; Marti GE ; Middleton, Dannie C. ; Shim YK ; Silver, Sharon R. ; Vogt RF
• Description:
  The pathogenesis of B-cell lymphoproliferative disorders in general and B-cell chronic lymphocytic leukaemia in particular appears to involve dysfunctional regulation of humoral and cellular immunity with the subsequent development of genetic aberrations in B cells. In theory, either component may arise de novo or may be influenced by environmental exposures including infectious agents, antigens, genotoxic chemicals, or radiation. As an intermediary within the exposure-disease continuum, monoclonal B-cell lymphocytosis may be a helpful biomarker for teasing out these various contributions to risk. This article introduces a series of papers that resulted from an International Workshop held in May 2007 entitled 'Monoclonal B-cell Lymphocytosis and Chronic Lymphocytic Leukemia: Environmental and Genetic Risk Factors'. Research efforts, such as those described in this issue, should lead to improved interventions, more predictive biomarkers, more effective treatments, and a greater appreciation of how the immune system functions over the entire human lifespan. [Description provided by NIOSH]
• Subjects:
  Antigens Biological Factors Biomarkers Blood Chemistry Environmental Exposure Environmental Health Environmental Pollution Genetics Hypersensitivity Lymphatic System Neoplasms Occupational Health Risk Assessment Risk Factors Safety

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• Keywords:
  Biological-effects Biological-factors Biological-function Biological-systems Cell-biology Cell-function Cell-metabolism Cellular-function Cellular-reactions Chemical-hypersensitivity Chemical-properties Chemical-synthesis Environmental-contamination Environmental-exposure Environmental-factors Environmental-hazards Environmental-medicine Genes Genetic-disorders Genetic-factors Genotoxic-effects Genotoxicity Leukemogenesis Leukocytes Leukocytolysis Lymphatic-cancer Lymphatic-system-disorders Pathogenicity Risk-factors

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• ISSN:
  0007-1048
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  139
• Issue:
  5
• NIOSHTIC Number:
  nn:20032890
• Citation:
  Br J Haematol 2007 Dec; 139(5):658-662
• Contact Point Address:
  Dr Y. K. Shim, Division of Health Studies, Agency for Toxic Substances and Disease Registry (MS: E-31), 1600 Clifton Road, NE, Atlanta, GA 30333
• Email:
  YShim@cdc.gov
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  British Journal of Haematology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ddb78df98beae0fe186289a7d2e0c64e6ae338c96b5eabd71f8df05b6316aa790de977b6a34743f3d8fa58cdd20c7a17d34decc7bca63237f267cabe0c036aac
• Download URL:
  https://stacks.cdc.gov/view/cdc/186688/cdc_186688_DS1.pdf
• File Type:
  [PDF - 66.91 KB ]